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Objectives To determine the strength and nature of the association between delirium and incident dementia in a population of older adult patients without dementia at baseline.
Design Retrospective cohort study using large scale hospital administrative data.
Setting Public and private hospitals in New South Wales, Australia between July 2001 and March 2020.
Participants Data were extracted for 650 590 hospital patients aged ≥65 years. Diagnoses of dementia and delirium were identified from ICD-10 (international classification of diseases, 10th revision) codes. Patients with dementia at baseline were excluded. Delirium-no delirium pairs were identified by matching personal and clinical characteristics, and were followed for more than five years.
Main outcome measures Cox proportional hazards models and Fine-Gray hazard models were used to estimate the associations of delirium with death and incident dementia, respectively. Delirium-outcome dose-response associations were quantifi