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Researchers discover a novel pathway that minimizes liver injury during transplantation

Researchers discover a novel pathway that minimizes liver injury during transplantation
medicalxpress.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from medicalxpress.com Daily Mail and Mail on Sunday newspapers.

Kenneth Dery , Brian Cheng , Hirofumi Hirao , Jerzy Kupiec Weglinski , Holger Eltzschig , Douglas Farmer , Kentaro Kadono , Hidenobu Kojima , Fady Kaldas , Shoichi Kageyama , Department Of Surgery , Gut Health , University Of South Carolina , Kyoto University , Science Translational Medicine , Hypoxia Inducible Factor , Yuan Zhai , Xiaoyi Yuan , Science Translational ,

Researchers receive $5.1 million to expand clinical trial of drug to prevent ARDS in COVID-19 patients


Researchers receive $5.1 million to expand clinical trial of drug to prevent ARDS in COVID-19 patients
Researchers evaluating whether an investigational oral drug, vadadustat, can help prevent acute respiratory distress syndrome (ARDS) in COVID-19 patients were awarded $5.1 million in funding from the U.S. Department of Defense (DOD) to expand the Phase II clinical trial at The University of Texas Health Science Center at HoustonQ (UTHealth).
Vadadustat is an investigational oral hypoxia-inducible factor prolyl hydroxylase inhibitor, or HIF-PHI, designed to mimic the physiologic effect of altitude on oxygen availability. At higher altitudes, the body responds to lower oxygen availability with stabilization of HIF, which can lead to improved oxygen delivery to tissues. Stabilization of HIF can help to dampen alveolar inflammation, a key problem that patients with COVID-19-associated lung disease are facing when they develop ARDS. The drug is investigational in the U.S. but ....

Katherineg Mcgovern , Holger Eltzschig , Emily Henderson , Ben Bobrow , Us Department Of Defense , Harris Health , Peer Reviewed Medical Research Program , Kathrineg Mcgovern Distinguished University Chair , Texas Medical Center , Department Of Anesthesiology , Translational Sciences , Akebia Therapeutics Inc , Emergency Medicine At Mcgovern Medical School , Uthealth Center , Mcgovern Medical School , Harris Health Lyndonb Johnson Hospital , Memorial Hermann City Medical Center , Texas Health Science Center , Perioperative Medicine , Govern Distinguished University , Reviewed Medical Research Program , Akebia Therapeutics , New Drug Application , Emergency Medicine , Memorial Hermann , Govern Distinguished Chair ,