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Searching for Surrogates: The Effort to Speed Up Drug Trials

Identifying surrogate endpoints for use in clinical trials that strongly predict clinical outcomes such as improved survival and quality of life is challenging. ....

United States , National Institutes Of Health , San Francisco , Amaru Kishan , Hiddol Heerspink , Vincent Planche , Juliaa Beaver , Carol Taylor Burds , Los Angeles , Karin Hoelzer , Fabio Conforti , Richard Pazdur , Anushka Walia , Emersony Chen , Ginny Beakes , Fady Ghali , Rare Diseases Information Center , Pilot Meeting Program , University Of Washington School Medicine , Oncology Center , University Of California , Oregon Health Science University In Portland , International Classification Of Disease , Drug Administration , European Renal Association , University Medical Center Groningen ,

Searching for Surrogates: The Effort to Speed Up Drug Trials

Identifying surrogate endpoints for use in clinical trials that strongly predict clinical outcomes such as improved survival and quality of life is challenging. ....

United States , National Institutes Of Health , San Francisco , Fabio Conforti , Vincent Planche , Fady Ghali , Karin Hoelzer , Ginny Beakes , Carol Taylor Burds , Amaru Kishan , Richard Pazdur , Hiddol Heerspink , Anushka Walia , Los Angeles , Emersony Chen , Juliaa Beaver , University Of California , Drug Administration , Pilot Meeting Program , European Institute Of Oncology , International Classification Of Disease , European Renal Association , University Of Washington School Medicine , Oncology Center , Amgen Inc , University Medical Center Groningen ,

Study Supports Total GFR Slope as a Surrogate Endpoint in Clinical Trials

GFR slope holds promise as a surrogate endpoint for clinical trials of new drugs for chronic kidney disease (CKD). ....

New South Wales , Hiddol Heerspink , University Medical Center Groningen , George Institute Of Global Health , European Renal Association , George Institute , Global Health ,

ADA: Tirzepatide Improves Kidney Outcomes in T2DM With Increased CV Risk

Fewer renal complications seen with tirzepatide versus insulin glargine in adults with T2D and increased cardiovascular risk. ....

United States , Eli Lilly , Hiddol Heerspink , American Diabetes Association , University Medical Center Groningen , Healthday News ,

Tirzepatide Slowed Progression of Chronic Kidney Disease in Patients with Type 2 Diabetes with Increased Cardiovascular Risk

/PRNewswire/ A pre-specified exploratory analysis from the SURPASS-4 trial showed tirzepatide, a novel once-weekly medication for the treatment of diabetes,. ....

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