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Brain organoid models reveal mechanisms linked to virus-induced microcephaly


Brain organoid models reveal mechanisms linked to virus-induced microcephaly
Researchers at IMBA - Institute of Molecular Biotechnology of the Austrian Academy of Sciences - demonstrate that different viruses can lead to brain malformations through diverse mechanisms by using human brain organoid models. The results are published in the journal
Cell Stem Cell.
Microcephaly, a term referring to developmental malformations of the fetal brain, can be caused by diverse infections during pregnancy. The infectious agents in question are grouped under the general term of TORCH pathogens, in reference to Toxoplasma gondii, Other, Rubella, Human Cytomegalovirus (HCMV), Herpes Simplex Viruses 1 and 2 (HSV-1 and HSV-2), as well as the more recently emerged Zika virus (ZIKV), which was also added to the group. The question whether all TORCH pathogens lead to microcephaly through the same mechanism has remained obscured due to the absence of suitable experimental models. Now, a te ....

Veronica Krenn , Emily Henderson , Molecular Biotechnology , Austrian Academy , Cell Stem , Human Cytomegalovirus , Herpes Simplex Viruses , Herpes Simplex , Herpes Simplex Virus , Zika Virus , எமிலி ஹென்டர்சன் , மூலக்கூறு உயிரி தொழில்நுட்பவியல் , ஆஸ்திரேலிய கலைக்கழகம் , செல் தண்டு , ஹெர்பெஸ் சிம்ப்ளக்ஸ் வைரஸ்கள் , உயிரி தொழில்நுட்பவியல் , ஹெர்பெஸ் சிம்ப்ளக்ஸ் , ஹெர்பெஸ் சிம்ப்ளக்ஸ் வைரஸ் , ஜிக வைரஸ் ,