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Real-World Patient Characteristics and Treatment Patterns Associated With Tucatinib Therapy in Patients With HER2+ Metastatic Breast Cancer

Jane Lowe Meisel, MD, presents data from a retrospective study investigating patient characteristics, treatment patterns, and clinical outcomes for tucatinib-based treatment in the real-world setting both overall and following fam-trastuzumab deruxtecan (T-DXd). ....

Jane Lowe Meisel , Real World Patient Characteristics , Patients With , Metastatic Breast , Lowe Meisel , Her2 Metastatic Breast Cancer , Tucatinib Based Treatment , Fam Trastuzumab Deruxtecan , T Dxd , Her2 Targeted Therapies , Active Brain Metasases ,

Remaining Unmet Needs in the Third-Line and Lessons from HER2CLIMB

Drs Tripathy and Kaklamani emphasize the most critical unmet needs for patients with HER2+ metastatic breast cancer in the third-line or higher settings and recap what the field previously learned from the HER2CLIMB trial of tucatinib/trastuzumab/capecitabine. ....

Sara Hurvitz , Breast Cancer , Her2 Breast Cancer , Her2 Positive Breast Cancer , Metastatic Breast Cancer , Third Line Therapy , Brain Metastases , Cns Metastases , Cumulative Toxicity , Cardiac Toxicity , Tyrosine Kinase Inhibitors , Topoisomerase Inhibitors , Antibody Drug Conjugates , Trastuzumab Deruxtecan , Trastuzumab Emtansine , T Dm1 , T Dxd , Cns Progression ,

Use of ADCs in the Second-Line Treatment of HER2+ mBC

Experts introduce the antibody-drug conjugates (ADCs) trastuzumab emtansine (T-DM1) and trastuzumab deruxtecan (T-DXd) and discuss clinical trial findings and potential use in special patient populations, such as those with brain metastases. ....

Sara Hurvitz , Melindal Telli , Heather Mcarthur , Breast Cancer , Her2 Breast Cancer , Her2 Positive Breast Cancer , Metastatic Breast Cancer , Second Line Therapy , Trastuzumab Deruxtecan , Trastuzumab Emtansine , T Dm1 , T Dxd , Destiny Breast03 , Db 03 , Interstitial Lung Disease , Blood Brain Barrier , Brain Metastases , Tuxedo 1 ,

HER2+ Breast Cancer Treatment Arena May Redefine the Roles of ADCs and Targeted Agents

Adrienne G. Waks, MD, spotlights the role of the HER2CLIMB regimen in patients with HER2-positive breast cancer with brain metastases, discusses unmet needs in the fourth- and later-line settings in HER2-positive disease, and explains the basis for the ongoing HER2CLIMB-02 and HER2CLIMB-04 trials within the broader ADC landscape. ....

United States , Dana Farber Cancer Institute , Adrienneg Waks , Clinical Research At Dana Farber Cancer Institute , Harvard Medical School , Clinical Research , Patients With Her2 Positive Breast Cancer , Adjuvant Trastuzumab Emtansine , Neoadjuvant Paclitaxel , Nd Pertuzumab , T Dm1 Plus Or Minus Tucatinib , T Dm1 Vs Trastuzumab Deruxtecan , Immune Checkpoint Blockade In Her2 Positive Disease , Her2climb 04 , Her2climb 02 , Brain Metastases , Antibody Drug Conjugate ,

Patient Profile: A 68-Year-Old Woman With HER2+ Metastatic Breast Cancer

Expert oncologist Virginia Kaklamani, MD, DSc, shares her perspectives on a patient case of HER2+ metastatic breast cancer (mBC) treated with multiple lines of therapy. ....

Improving Outcomes , Breast Cancer , Translating Evidence , Clinical Practice , Year Old Woman With , Metastatic Breast Cancer , Virginia Kaklamani , Her2 Positive , Her2 Breast Cancer , Interstitial Lung Disease , Thp Therapy , Cleopatra Trial , Cleopatra Regimen , Cleopatra Study , Trastuzumab Deruxtecan , T Dxd , Destiny Breast03 , Trastuzumab Emtansine , Third Line Therapy , Third Line Treatment , Later Line Therapy , Her2climb Trial , Brain Mets , Brain Metastases ,