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Clinical effectiveness of an online supervised group physical and mental health rehabilitation programme for adults with post-covid-19 condition (REGAIN study): multicentre randomised controlled trial

Objective To evaluate whether a structured online supervised group physical and mental health rehabilitation programme can improve health related quality of life compared with usual care in adults with post-covid-19 condition (long covid).

Design Pragmatic, multicentre, parallel group, superiority randomised controlled trial.

Setting England and Wales, with home based interventions delivered remotely online from a single trial hub.

Participants 585 adults (26-86 years) discharged from NHS hospitals at least three months previously after covid-19 and with ongoing physical and/or mental health sequelae (post-covid-19 condition), randomised (1:1.03) to receive the Rehabilitation Exercise and psycholoGical support After covid-19 InfectioN (REGAIN) intervention (n=298) or usual care (n=287).

Interventions Best practice usual care was a single online session of advice and support with a trained practitioner. The REGAIN intervention was delivered online over eight ....

United Kingdom , Scott Mcguire , David Mcwilliams , Helen Atherton , Jonathon Prosser , Beatriz Lara , Martin Underwood , Patrick Sawdon , Francesca Denton , Rachel Potter , Peter Heine , Emma Padfield , Gordon Mcgregor , Nigel Edwards , Shilpa Patel , Sharisse Alleyne , Dalan Bush , Georgie Ray , Danielle Hale , Charles Abraham , Susanne Finnegan , Harbinder Sandhu , James Mason , Julie Bruce , Vivien Nichols , Rowena Williams ,

Acute rehabilitation following traumatic anterior shoulder dislocation (ARTISAN): pragmatic, multicentre, randomised controlled trial

Objective To assess the effects of an additional programme of physiotherapy in adults with a first-time traumatic shoulder dislocation compared with single session of advice, supporting materials, and option to self-refer to physiotherapy.

Design Pragmatic, multicentre, randomised controlled trial (ARTISAN).

Setting and participants Trauma research teams at 41 UK NHS Trust sites screened adults with a first time traumatic anterior shoulder dislocation confirmed radiologically, being managed non-operatively. People were excluded if they presented with both shoulders dislocated, had a neurovascular complication, or were considered for surgical management.

Interventions One session of advice, supporting materials, and option to self-refer to physiotherapy (n=240) was assessed against the same advice and supporting materials and an additional programme of physiotherapy (n=242). Analyses were on an intention-to-treat basis with secondary per protocol analyses.

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East Suffolk , United Kingdom , North Yorkshire , West Suffolk , United Kingdom General , Glasgow City , City Of , West Midlands , Henry Nwankwo , Christopher Ratcliffe , Hannah Riley , Nicola Parker , Maria Mestre , Rachel Chester , Alison Armstrong , Rebeccas Kearney , Hannah Craig , Aileen Nacorda , Kathryn Allison , Fiona Carleton , Chandramohan Panneerselvam , Leanne Dymott , David Torgerson , David Bailey , Hayley Potter , Sarah Melling ,