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DNA building blocks regulate inflammation


Credit: Hans-Georg Sprenger
Mitochondria are the energy suppliers of our body cells. These tiny cell components have their own genetic material, which triggers an inflammatory response when released into the interior of the cell. The reasons for the release are not yet known, but some cardiac and neurodegenerative diseases as well as the ageing process are linked to the mitochondrial genome. Researchers at the Max Planck Institute for Biology of Ageing and the CECAD Cluster of Excellence in Ageing research have investigated the reasons for the release of mitochondrial genetic material and found a direct link to cellular metabolism: when the cell s DNA building blocks are in short supply, mitochondria release their genetic material and trigger inflammation. The researchers hope to find new therapeutic approaches by influencing this metabolic pathway. ....

Patrick Giavalisco , Denise Ehrentraut , Dusanka Milenkovic , Hendrik Nolte , Thomas Macvicar , Kai Uwe Fiedler , Amir Bahat , Hans Georg Sprenger , Steffen Hermans , Thomas Langer , Nina Bonekamp , Max Planck Institute , Georg Sprenger , Katharina Ried , ஹென்ட்ரிக் நோல்ட் , தாமஸ் மகுவிகர் , ஹான்ஸ் ஜார்ஜ் ஸ்ப்ரெஞ்சர் , தாமஸ் லாங்கர் ,