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SITC 2023: Preclinical development of LYL119, a ROR1-targeted CAR T-cell product incorporating four novel T-cell reprogramming technologies to overcome barriers to effective cell therapy for solid tumors -November 04, 2023 at 12:52 pm EDT

Phase 1 Trial of LYL797, a ROR1-Targeted CAR T-Cell Therapy Enhanced With Genetic and Epigenetic Reprogramming, in

Advanced Triple-Negative. ....

New York , United States , South San Francisco , Georgetown University , District Of Columbia , Fred Hutchinson Cancer Research Center , University Hospital , Memorial Sloan Kettering Cancer Center , Thomas Jefferson University Hospital , San Diego , Lubnan Chaudhary , Maryc Lessig , Hirva Mamdani , Jenniferm Specht , Yeonhee Kim , Robertoa Leon Ferre , Michael Hurwitz , Hajime Hiraragi , Yazan Migdady , Usama Gergis , Hemants Murthy , Jonathan Goldman , Los Angeles , Lyell Immunopharma , Madison Fagan , Sarah Fitzsimmons ,

Dr Murthy on the Use of CAR T-Cell Therapy in Elderly or Frail Patients With B-Cell Lymphomas

Hemant S. Murthy, MD, discusses the evolving use of CAR T-cell therapy for elderly or frail patients with relapsed/refractory B-cell lymphomas. ....

Hemants Murthy , Mayo Clinic , Hematopoietic Cell Transplantation , Comorbidity Index , Cart Cell Therapy , B Cell Lymphoma , Elderly Or Frail Patients ,

Further Research Is Needed to Maximize Efficacy of Current Treatment Options in Hematologic Malignancies

Ricardo D. Parrondo, MD, highlights the current use of covalent BTK inhibitors in chronic lymphocytic leukemia, potential roles for the non-covalent BTK inhibitor pirtobrutinib, and the importance of future research on time-limited treatment options for patients with newly diagnosed chronic lymphocytic leukemia. ....

United States , Mayo Clinic In Rochester , Hemants Murthy , Candidoe Rivera , Muhamad Alhaj Moustafa , Ricardod Parrondo , National Comprehensive Cancer Network , Science Summit , Mayo Clinic ,

Strategies to Improve Manufacturing Time, Mitigate Toxicities of CAR T-Cell Therapy Remain a Focus in R/R LBCL

Hemant S. Murthy, MD, emphasizes the importance of an accelerated manufacturing process for CAR T-cell therapy, discusses the use of CAR T-cell therapy in older and frail patients, and highlights toxicity management strategies that have implemented and are under evaluation for patients receiving CAR T-cell therapy. ....

United States , Michaelj Dickinson , Los Angeles , Hemants Murthy , Memorial Sloan Kettering Cancer Center , University Of California , Science Summit , Mayo Clinic , Hematopoietic Cell Transplantation , Comorbidity Index , Jae Park , Cart Cell Therapy ,