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T-cell activator offers protection against coronaviruses in immunocompromised cancer patients

T-cell activator offers protection against coronaviruses in immunocompromised cancer patients
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Frankfurt Am Main , Beate Armbruster , Helmut Salih , Juliane Walz , Jonass Heitmann , Jonas Heitmann , University Hospital Of Tuebingen , Nature Communications , University Hospital , Medical Faculty , Internal Medicine ,

CORAT Therapeutics GmbH obtained regulatory authorization for clinical phase Ib/II trial with the SARS-CoV-2 neutralizing human antibody COR-101


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BRAUNSCHWEIG, Germany, March 16, 2021 /PRNewswire/ CORAT Therapeutics GmbH obtained the regulatory approval as well as the favorable opinion from the central ethics committee to conduct the clinical phase Ib/II trial with its antibody COR-101 against COVID-19. COR-101 is a neutralizing human antibody that binds to the receptor binding domain (RBD) of the spike protein of SARS-CoV-2 and is endowed with a unique structural design. It aims to improve the treatment situation of hospitalized COVID-19 patients with moderate to severe disease, a patient group which currently cannot be treated appropriately due to the lack of effective medication. The innovative safety design of COR–101 prevents any Fc-gamma receptor binding and avoids the risk of antibody dependent enhancement (ADE) of disease. The antibody was isolated from convalescent patients and was developed with an accelerated development strategy under guidance of the German regul ....

New York , United States , Czech Republic , United Kingdom , Lower Saxony , Helmut Salih , Andreas Herrmann , Thomas Schirrmann , University Of Technology , University Hospital In Tuebingen , University Hospital , Yumab Inc , புதியது யார்க் , ஒன்றுபட்டது மாநிலங்களில் , செக் குடியரசு , ஒன்றுபட்டது கிஂக்டம் , கீழ் சாக்சனி , ஹெல்முட் ஸ்யாலி , ஆண்ட்ரியாஸ் ஹெர்மன் , பல்கலைக்கழகம் ஆஃப் தொழில்நுட்பம் , பல்கலைக்கழகம் மருத்துவமனை ,