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Artificial intelligence has potential to counter vaccine hesitancy while building trust in vaccines, but it must be deployed ethically and responsibly, argue Heidi Larson and Leesa Lin Given the sluggish pace of traditional scientific approaches, artificial intelligence (AI), particularly generative AI, has emerged as a significant opportunity to tackle complex health challenges, including those in public health.1 Against this backdrop, interest has focused on whether AI has a role in bolstering public trust in vaccines and helping to minimise vaccine hesitancy, which the World Health Organization named as one of the top 10 global health threats.2 Vaccine hesitancy is a state of indecision before accepting or refusing a vaccination.3 It is a dynamic and context specific challenge that varies across time, place, and vaccine type. It is influenced by a range of factors, including sociocultural and political dynamics, as well as individual and group psychology. Its multifaceted and tem

Charles shey wiysongeHeidij larsonLeesa linHeidi larsonEmma veitchAlison buttenheimHealth online initiativeTechnology commission of the governmentWorld health organizationTechnology commissionHong kong special administrativeVaccine confidence projectMerck investigator initiated studiesAdvancing health online initiativeBriony swire thompsonCharles shey