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"Stress biology: Complexity and multifariousness in health and disease" by Matthias P. Mayer, Laura Blair et al.

Preserving and regulating cellular homeostasis in the light of changing environmental conditions or developmental processes is of pivotal importance for single cellular and multicellular organisms alike. To counteract an imbalance in cellular homeostasis transcriptional programs evolved, called the heat shock response, unfolded protein response, and integrated stress response, that act cell-autonomously in most cells but in multicellular organisms are subjected to cell-nonautonomous regulation. These transcriptional programs downregulate the expression of most genes but increase the expression of heat shock genes, including genes encoding molecular chaperones and proteases, proteins involved in the repair of stress-induced damage to macromolecules and cellular structures. Sixty-one years after the discovery of the heat shock response by Ferruccio Ritossa, many aspects of stress biology are still enigmatic. Recent progress in the understanding of stress responses and molecular chaperone ....

United States , Al Iskandariyah , Ferruccio Ritossa , International Symposium , Heat Shock Proteins , Old Town Alexandria , Heat Shock Response , Eat Shock Transcription Factors , Molecular Chaperones , Protein Folding Diseases , Stress Response ,

Russian Scientists Discover Gene Responsible for Stroke Severity

Russian scientists from the National Research University ‘Belgorod State University’ (BelSU), as part of an international scientific team, have identified a link between the structure of a gene encoding heat shock proteins and the course of ischemic stroke. ....

United Kingdom , Russian Federation , World Health Organization , Russian Federation Priority , National Research University Belgorod State Bel , National Research University , Belgorod State University , Russian Science , Belgorod University , Russian Biology , Ussian Genetics , Stroke Severity , Russian Scientist , Erebral Blood Circulation , Ischemic Stroke , Heat Shock Proteins ,