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Researchers closer to gene therapy that would restore hearing for the congenitally deaf


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CORVALLIS, Ore. - Researchers at Oregon State University have found a key new piece of the puzzle in the quest to use gene therapy to enable people born deaf to hear.
The work centers around a large gene responsible for an inner-ear protein, otoferlin. Mutations in otoferlin are linked to severe congenital hearing loss, a common type of deafness in which patients can hear almost nothing.
For a long time otoferlin seemed to be a one-trick pony of a protein, said Colin Johnson, associate professor of biochemistry and biophysics in the OSU College of Science. A lot of genes will find various things to do, but the otoferlin gene had appeared only to have one purpose and that was to encode sound in the sensory hair cells in the inner ear. Small mutations in otoferlin render people profoundly deaf. ....

Oregon State University , United States , Paroma Chatterjee , Sean Bugel , Aayushi Manchanda , Robyn Tanguay , Josephine Bonventre , Colin Johnson , Oregon State College Of Science , National Institutes Of Health , College Of Science , Researchers At Oregon State University , College Of Agricultural Sciences , Molecular Biology , Oregon State College , National Institutes , Medicine Health , Hearing Speech , Gene Therapy , ஓரிகந் நிலை பல்கலைக்கழகம் , ஒன்றுபட்டது மாநிலங்களில் , பரோமா சாட்டர்ஜி , ஆயுஷி மஞ்சந்தா , ராபின் தன்குாய் , கொலின் ஜான்சன் , ஓரிகந் நிலை கல்லூரி ஆஃப் அறிவியல் ,

Sounds familiar: A speaker identity-controllable framework for machine speech translation


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IMAGE: Voice conversion is carried out by selecting target speaker embedding from speaker codebook. Voice characteristic can be independently controlled via principal components of speaker embedding.
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Credit: Masato Akagi
Ishikawa, Japan - Robots today have come a long way from their early inception as insentient beings meant primarily for mechanical assistance to humans. Today, they can assist us intellectually and even emotionally, getting ever better at mimicking conscious humans. An integral part of this ability is the use of speech to communicate with the user (smart assistants such as Google Home and Amazon Echo are notable examples). Despite these remarkable developments, they still do not sound very human . ....

Masato Akagi , Star Generative Adversarial Network , Tokyo Institute Of Technology , Japan Advanced Institute Of Science , Google Home , Amazon Echo , Japan Advanced Institute , Professor Masato Akagi , Information Science , Tokyo Institute , Medicine Health , Hearing Speech , Language Linguistics Speech , டோக்கியோ நிறுவனம் ஆஃப் தொழில்நுட்பம் , கூகிள் வீடு , அமேசான் எதிரொலி , தகவல் அறிவியல் , டோக்கியோ நிறுவனம் , மருந்து ஆரோக்கியம் ,

Biomedical sciences researcher gets $2.3 million grant to study inflammation in infectious diseases


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IMAGE: Dr. Jian-Dong Li, professor and director of the Institute for Biomedical Sciences at Georgia State University
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Credit: Georgia State University
ATLANTA Dr. Jian-Dong Li, professor and director of the Institute for Biomedical Sciences at Georgia State University, has received a five-year, $2.3 million federal grant to study how overactive inflammatory response is caused in infectious diseases and to further develop novel anti-inflammatory therapeutics.
The grant from the National Institutes of Health s National Institute on Deafness and Other Communication Disorders will be used to understand excess mucus production and inflammation in otitis media, an infection of the middle ear, the air-filled space behind the eardrum. ....

United States , Jian Dong Li , Georgia Research Alliance Eminent Scholar In Inflammation , Biomedical Sciences , Georgia State University , National Institutes , National Institute , Georgia Research Alliance Eminent Scholar , Medicine Health , Hearing Speech , Infectious Emerging Diseases , Pharmaceutical Science , ஒன்றுபட்டது மாநிலங்களில் , உயிர் மருத்துவ அறிவியல் , ஜார்ஜியா நிலை பல்கலைக்கழகம் , தேசிய நிறுவனங்கள் , தேசிய நிறுவனம் , ஜார்ஜியா ஆராய்ச்சி கூட்டணி சிறந்த அறிஞர் , மருந்து ஆரோக்கியம் ,