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A novel tuberculosis regimen shortens treatment course for patients

A phase III clinical trial led by an investigator at the Medical University of South Carolina found that a novel four-month regimen was just as effective at treating tuberculosis as the standard six-month regimen. The findings are reported in the May 6, 2021 New England Journal of Medicine. ....

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Aging impairs anti-tumor T-cell response via mitochondria dysfunction

MUSC Hollings Cancer Center researchers are finding solutions to the aging-related changes that reduce anti-cancer immunity. Their work, published in Cell Reports, sheds light on an important pathway that cannot be ignored during cancer treatment. ....

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Hollings Cancer Center scientist receives Melanoma Research Alliance grant

MUSC Hollings Cancer Center researcher Haizhen (Jen) Wang, Ph.D., recently was awarded a three-year $225,000 Young Investigator grant from the Melanoma Research Alliance. The grant will help Wang further her research on T-cells and the tumor microenvironment in melanoma patients. ....

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Chemical changes to peptide siRNA-carrier enhance gene silencing for future cancer drugs

Hollings researchers found a modified peptide carrier that was delivering the siRNA drug by adhering to and potentially moving along cell filopodia, leading to more efficient cell entry and improved gene silencing. ....

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Uninsured cancer patients 60-64 face worse outcomes than Medicare beneficiaries aged 66-69

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IMAGE: Dr. Gerard Silvestri was very surprised by his findings, as younger patients typically have better outcomes than their older counterparts with similar stages and types of cancer.
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Credit: MUSC
MUSC Hollings Cancer Center lung cancer researcher Gerard Silvestri, M.D., found that a lack of insurance leads to worse cancer survival than for those with Medicare, in a paper published in the May issue of
Health Affairs. This work, a joint effort between Silvestri and researchers at the American Cancer Society, highlights the current dire barrier in medical care: Many people cannot take advantage of the newer potentially lifesaving treatments due to the high costs. ....

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