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Researchers discover a new paradigm for how biological switches are regulated

Quantitative Biosciences Institute (QBI) researchers at UC San Francisco have discovered a new paradigm for how fundamental biological switches, proteins that can be turned on and off to control processes like cell differentiation, cell growth, and transport within a cell, are regulated at the molecular level, specifically by molecules binding at newly discovered sites far away from the main binding site, and the broader impacts these changes have on a cellular level. ....

Tina Perica , Chan Zuckerberg Biohub , Tanja Kortemme , Nevan Krogan , Christopher Mathy , Emily Henderson , Kortemme Lab , Head Of The Kortemme Lab , Quantitative Biosciences Institute , Biosciences Institute , Chan Zuckerberg Biohub Investigator ,