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Swelling Along Brain's Axons May Be True Culprit in Alzheimer's Disease

The formation of plaques can cause the accumulation of spheroid-shaped swellings along axons near the amyloid plaque deposits. The swellings are caused by lysosomes, which digest cellular waste. As the swelling enlarges, it can block the transmission of signals from one area of the brain to another. ....

Harrym Zimmerman , Jaime Grutzendler , Nature Communications , Yale School Of Medicine , Viola Spinelli Professor , Yale School , Bill Hathaway , Peng Yuan , Neuroscience Newsletter ,

Swelling along brain's axons may be true culprit in Alzheimer's disease

Yale researchers have found that the disease’s debilitating symptoms may be the result of swelling caused by amyloid plaques in the brain. ....

Harrym Zimmerman , Jaime Grutzendler , Yale School Of Medicine , Viola Spinelli Professor , Yale School , Yale University , Press Releases ,

PATHS helps students from underrepresented backgrounds realize med school dreams


May 10, 2021
Photo by Nelson Perez Catalan
Nelson Perez Catalan discovered he was interested in pursuing science while working at a student job at the University of Oregon cleaning glass in the labs. He found himself drawn to research around the brain, and thought about pursuing an MD/PhD, but there was no medical school at his university and as a transplant from Chile, he says much of the U.S. college process was mystifying to him. He knew he wanted to continue the research he’d begun on a type of glial cell in the brain called astrocytes. He attended the University of Chicago for his post-baccalaureate and continued his work examining how astrocytes coordinate neuron assembly, moving from fruit flies to mouse models. But he wasn’t sure about next steps. ....

Titilayo Omotade , Giovanna Guerrero Medina , Harrym Zimmerman , Nelson Perez Catalan , Linda Jackson , Melanie Brady , Jaime Grutzendler , Yale School Of Medicine , University Of Oregon , National Institutes Of Health , Yale Ciencia Academy , University Of Chicago , Office Of Diversity , Program To Advance Training In Health , Nelson Perez , Advance Training , Yale School , Yale March , Viola Spinelli Professor , National Institutes , ஜியோவானா கெரெரோ மதினா , லிண்டா ஜாக்சன் , மெலனி பிராடி , யேல் பள்ளி ஆஃப் மருந்து , பல்கலைக்கழகம் ஆஃப் ஓரிகந் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் ,