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Designing effective multidrug-resistant-TB treatments based on DNA sequencing

Designing effective multidrug-resistant-TB treatments based on DNA sequencing
Globally, tuberculosis is the most common bacterial infectious disease leading to death. The pathogen causing tuberculosis, Mycobacterium tuberculosis, has a number of peculiarities. One is that it is growing very slowly. While other typical pathogens, such as pneumococcal and pseudomonads, can already be identified by their growth in the microbiological laboratory in the first 72 hours, several weeks usually pass before tuberculosis bacteria grow in the lab. Thus it often takes one to two months before the efficacy of individual medicines can be tested.
However, these efficacy tests are essential for the effective treatment of multidrug-resistant tuberculosis (MDR-TB), which is becoming increasingly common. In these cases, the pathogen has become resistant, i.e. insensitive, to the best tuberculosis drugs, rifampicin and isoniazid. This is due to changes in the genome, so-called mutations, which ....

Harald Hoffmans , Florian Maurer , Christoph Lange , Stefan Niemann , Matthias Merker , Hans Peter Grobbel , Emily Henderson , Research Center Borstel , Borstel Department Of Medicine , Research Center , Peter Grobbel , Professor Matthias Merker , Borstel Department , National Reference Laboratory , Tuberculosis Bacteria , Antibiotic Resistance , புளோரியன் ம Ure ரர் , கிறிஸ்டோஃப் லாங்கே , ஸ்டீபன் நிஎமான்ன் , எமிலி ஹென்டர்சன் , ஆராய்ச்சி மையம் போர்ஸ்டல் , ஆராய்ச்சி மையம் , தேசிய குறிப்பு ஆய்வகம் ,

Tailor-made therapy of multi-resistant tuberculosis

The successful treatment of multidrug-resistant tuberculosis requires clarification in advance as to which antibiotics the pathogens are resistant to. Classic testing is very time-consuming and delays the start of therapy. Researchers from the Research Center Borstel and the DZIF have now prepared a catalogue of all mutations in the genome of tuberculosis bacteria and on the basis of a genome sequencing can quickly and cheaply predict which medicines are most effective for tuberculosis treatment. ....

Harald Hoffmans , Florian Maurer , Christoph Lange , Stefan Niemann , Matthias Merker , Hans Peter Grobbel , Research Center Borstel , Borstel Department Of Medicine , Research Center , Peter Grobbel , Professor Matthias Merker , Borstel Department , National Reference Laboratory , Tuberculosis Bacteria , Medicine Health , Infectious Emerging Diseases , புளோரியன் ம Ure ரர் , கிறிஸ்டோஃப் லாங்கே , ஸ்டீபன் நிஎமான்ன் , ஆராய்ச்சி மையம் போர்ஸ்டல் , ஆராய்ச்சி மையம் , தேசிய குறிப்பு ஆய்வகம் , மருந்து ஆரோக்கியம் ,