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Positive Trial of Methotrexate in Hand OA Has Modest Results

A randomized controlled trial of methotrexate in inflammatory hand OA demonstrated clinical benefit, suggesting a potential role for immunosuppression in a subset of patients with an inflammatory OA phenotype.

South australiaUnited statesAmandae nelsonFlavia cicuttiniIdak haugenMusculoskeletal unit at monash universityNational healthHealth assessment questionnaireDiakonhjemmet hospital centerAmerican college of rheumatologyResearch council of australiaTreat hand osteoarthritisMusculoskeletal unitMonash universityAlfred hospitalAmerican college

Osteoarthritis Cases Projected to Balloon Over Next 30 Years

An estimated 595 million people worldwide are affected now, and researchers predict levels will rise as much as 95% by 2050 as the population ages.

United statesJaimied steinmetzInstitute for health metricsMelinda gates foundationInstitute of boneGlobal alliance for musculoskeletal healthGlobal burdenHealth metricsJoint researchGlobal allianceOsteoarthritis oaSteoarthritis generalizedA osteoarthritisEgenerative joint disease djdRthritis degenerativeEneralized osteoarthritis

Denosumab May Halt Erosive Hand Osteoarthritis Progression

In a randomized clinical trial, denosumab seemed to halt progression of erosive hand osteoarthritis, but had a delayed impact on pain.

United statesDavidt felsonRuth wittoekGhent university scoring systemGhent belgium universityAmerican college of rheumatologyBoston universityAmerican collegeOsteoarthritis oaSteoarthritis generalizedA osteoarthritisEgenerative joint disease djdRthritis degenerativeEneralized osteoarthritisDegenerative arthritisPain management

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