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Cell banks in drug development - how frozen cells drive medical progress

Cell banks are generally known for various fields of application - while many are familiar with the concept of freezing cells for reproductive purposes, others may have come across cell banking in the context of stem cell preservation. ....

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Continuous Processes: Keeping Them Safe from Viruses


Continuous Processes: Keeping Them Safe from Viruses
Sponsored Content by Pall CorporationMay 21 2021
Virus safety is a crucial part of biopharmaceutical manufacturing. There are intrinsic risks related to virus safety in the handling of animal cell culture. Chinese Hamster Ovary (CHO) cell lines are the most frequently found production platform for expressing glycosylated proteins and monoclonal antibodies.
Image credit: Pall Corporation
Due to their rodent origins, CHO cell lines can harbor endogenous retroviruses or retrovirus-like particles. Additional virus safety risks arise from the potentiality that the cell culture could be compromised by adventitious viruses.
Consequently, the regulatory expectation for manufacturing platforms is to demonstrate the capacity to eliminate or inactivate a broad range of viruses to limit the impact of viruses on the safety of patients. ....

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