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LA JOLLA, CA Scientists at Scripps Research, University of Chicago and Icahn School of Medicine at Mount Sinai have identified a new Achilles’ heel of ....
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Antibody Response to Flu Shaped by Pre-Existing Immunity December 14, 2020 Receiving the seasonal flu vaccine each year, in addition to seasonal infections, exposes people to a lifetime of building up immune responses to influenza antigens. Yet, it remains unclear whether infection and vaccination induce distinct influenza-specific immunological memory. A team led by researchers at the University of Chicago compared antibodies produced by individuals after influenza infection or vaccination. The authors found that a person’s antibody response to influenza viruses is dramatically shaped by their pre-existing immunity, and that the quality of this response differs in individuals who are vaccinated or naturally infected. Their results highlight the importance of receiving the annual flu vaccine to induce the most protective immune response. ....
Pre-existing immunity shapes a person s antibody response to influenza viruses New research by scientists at the University of Chicago suggests a person s antibody response to influenza viruses is dramatically shaped by their pre-existing immunity, and that the quality of this response differs in individuals who are vaccinated or naturally infected. Their results highlight the importance of receiving the annual flu vaccine to induce the most protective immune response. The researchers found that most of the initial antibodies stimulated after both influenza infections and influenza vaccinations came from old B cells a type of white blood cell that secretes antibodies indicating the immune system s memory plays a major role in how the body responds early on to a viral infection. These antibodies displayed higher reactivity toward strains of influenza that circulated during an individual s childhood compared to more recent strains. ....
E-Mail New research by scientists at the University of Chicago suggests a person s antibody response to influenza viruses is dramatically shaped by their pre-existing immunity, and that the quality of this response differs in individuals who are vaccinated or naturally infected. Their results highlight the importance of receiving the annual flu vaccine to induce the most protective immune response. The researchers found that most of the initial antibodies stimulated after both influenza infections and influenza vaccinations came from old B cells a type of white blood cell that secretes antibodies indicating the immune system s memory plays a major role in how the body responds early on to a viral infection. These antibodies displayed higher reactivity toward strains of influenza that circulated during an individual s childhood compared to more recent strains. ....