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Combo Therapy Boosts Response in Hairy Cell Leukemia


As pointed out by Tiacci and colleagues, the
BRAF V600E mutation is known to be the causal genetic event of HCL. Vemurafenib is a BRAF inhibitor, and while two studies showed it had activity in patients with refractory or relapsed HCL, relapses were common, with one study showing a median relapse-free survival of 9 months after the end of treatment.
Rituximab is myelotoxic and may complement intracellular BRAF inhibition in killing leukemic cells by means of a different mechanism, the authors explained.
This phase II single-center trial included 30 patients with refractory or relapsed HCL. Patients had previously received a median of three therapies. The study treatment regimen consisted of 8 weeks of oral vemurafenib (960 mg twice daily) and eight intravenous rituximab infusions (375 mg/m ....

United States , Michael Grever , Enrico Tiacci , Mike Bassett , University Of Perugia , Ohio State University In Columbus , Hairy Cell Leukemia Foundation , Lymphoma Society , New England Journal , Ohio State University , England Journal , Englj Med , Hairy Cell Leukemia , Chronic Leukemia , ஒன்றுபட்டது மாநிலங்களில் , மைக் பாசெட் , ஓஹியோ நிலை பல்கலைக்கழகம் இல் கொலம்பஸ் , ஹேரி செல் லுகேமியா அடித்தளம் , லிம்போமா சமூகம் , புதியது இங்கிலாந்து இதழ் , ஓஹியோ நிலை பல்கலைக்கழகம் , இங்கிலாந்து இதழ் , ஹேரி செல் லுகேமியா , நாள்பட்ட லுகேமியா ,

$17 Million To Boost Leukemia & Lymphoma Research


$17 Million To Boost Leukemia & Lymphoma Research
December 23, 2020
The Leukemia & Lymphoma Society (LLS), Rye Brook, N.Y., has inked deals with cancer institutions, foundations and philanthropists to fund roughly $9 million in new research grants in 2020, with up to $8 million more in funding anticipated for early 2021. The funds will underwrite research in improved treatments and potential cures for those with leukemia, lymphoma, myeloma and a variety of blood cancers.
The new funding comes as the global medical community has focused on research aimed at mitigating the coronavirus pandemic. As a result, institutes, labs and organizations have scaled back their research investments, and care facilities have faced unexpected shortages. ....

Lee Greenberger , Foundation For Childhood Cancer Research , Hairy Cell Leukemia Foundation , Leukemia Lymphoma Society , Md Anderson Cancer Center , Moffitt Cancer Center , Snowdome Foundation , Leukemia Foundation , Mark Foundation For Cancer Research , Jackson Laboratory , Lymphoma Society , Rye Brook , Mark Foundation , Cancer Research , Rally Foundation , Childhood Cancer Research , Cancer Center , Moffitt Cancer , Scientific Officer , அடித்தளம் க்கு குழந்தை பருவம் புற்றுநோய் ஆராய்ச்சி , ஹேரி செல் லுகேமியா அடித்தளம் , லுகேமியா லிம்போமா சமூகம் , ம்ட் ஆண்டர்சன் புற்றுநோய் மையம் , மாஃபிட் புற்றுநோய் மையம் , லுகேமியா அடித்தளம் , குறி அடித்தளம் க்கு புற்றுநோய் ஆராய்ச்சி ,

Collaboration Driving Progress: LLS Forms Alliances with Leading Cancer Institutions and Foundations to Co-Fund nearly $17 million in New Research Grants


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RYE BROOK, N.Y., Dec. 14, 2020 /PRNewswire/  As the world confronts a viral pandemic not seen in the past 100 years, the reverberations are being felt across every sector, from healthcare to the economy, education, business and science, including the blood cancer community. Blood cancers don t stop for the Covid-19 virus and the urgent need for collaboration to address these challenges has never been starker.
In response, The Leukemia & Lymphoma Society (LLS) today announced it has forged significant alliances with premier foundations, cancer institutions and philanthropic individuals, bringing their collective resources to bear to co-fund approximately $9 million in new research grants, with up to $8 million more funding anticipated over the next year. This cooperation will allow LLS to continue driving forward impactful research to find better treatments and cures for patients with leukemia, lymphoma, myeloma and other blood c ....

United States , South Australia , Harryt Mangurian Jr , Kimberly Stegmaier , Johanna Melo Cardenas , Jennifer Trowbridge , Frederick Locke , Sylvain Simon , Therese Vu , Stanford Universityanddaniel Thomas , Ravindra Majeti , Lee Greenberger , John Pimanda , Andrea Greif , Rising Tide Foundation For Clinical Cancer Research , National Cancer Institute , Foundation For Childhood Cancer Research , Marian Falk Medical Research , Md Anderson Cancer Center , Sarah Cannon Foundation , Mark Foundation , Dana Farber Cancer Institute , Fred Hutchinson Cancer Research Center , Australia Health , Children Initiative , National Institutes Of Health ,