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Cureus | Multidrug-Resistant Musculoskeletal Tuberculosis: An Aggressive Clinical, Radiological and Molecular Confirmation With Genotypic Drug Susceptibility Testing Approach

Introduction

Increasing evidence suggests that musculoskeletal tuberculosis (MSTB) causes significant morbidity due to the late presentation of symptoms and lack of accurate diagnosis. We aimed to assess the utility of two modalities, viz. radiology and molecular methods, in the early diagnosis of MSTB. Also, the rate of resistance to two basic first-line antitubercular drugs in musculoskeletal TB cases among clinically suspected patients was analyzed.

Methods

Samples from 119 patients with clinical suspicion of musculoskeletal TB were included. A radiological workup of patient and smear microscopy, mycobacterial culture, real-time multiplex polymerase chain reaction (PCR), cartridge based nucleic acid amplification test (CBNAAT), and line probe assay (LPA) of samples were carried out.

Results

Maximum positivity (69.74%) was observed by real-time multiplex, followed by CBNAAT and LPA (68.9%), mycobacterial culture (40.3%), and smear micros ....

United States , Rheinland Pfalz , Franklin Lakes , Hain Lifescience , India Ltd , Himalayan Institute Of Medical Sciences , Research Committee , North India , Himalayan Institute , Medical Sciences , Step Nested Kit , Black Bio Biotech ,

Treatment outcomes 24 months after initiating short, all-oral bedaquiline-containing or injectable-containing rifampicin-resistant tuberculosis treatment regimens in South Africa: a retrospective cohort study

Treatment outcomes 24 months after initiating short, all-oral bedaquiline-containing or injectable-containing rifampicin-resistant tuberculosis treatment regimens in South Africa: a retrospective cohort study
thelancet.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from thelancet.com Daily Mail and Mail on Sunday newspapers.

South Africa , United States , Rheinland Pfalz , Mtbdrsl Hain Lifescience , National Department Of Health , University Of Witwatersrand Johannesburg , Human Research Ethics Committee , Hain Lifescience , National Department , Clinical Guidance , Injectable Free Regimens , Rifampicin Resistant Tuberculosis , Transl Med ,

Mycobacterium mageritense Lymphadenitis in Child

Mycobacterium mageritense Lymphadenitis in Child
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Bruker Daltonics , Hain Lifescience , Laboratory Standards Institute , Genotype Mycobacterium , Hospital Universitario La Paz ,