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BET inhibitors combined with JAK inhibitors well-tolerated with myelofibrosis

BET inhibitors combined with JAK inhibitors well-tolerated with myelofibrosis
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San Diego , United States , Mindy Valcarcel , Bydavid Statman , Jakafi Incyte , Haifa Kathrin Al Ali , Bristol Myers Squibb , Krukenberg Cancer Center , University Hospital ,

BMS-986158–Based Combos May Provide Another Viable Treatment Approach in Myelofibrosis

Haifa Kathrin Al-Ali, MD, provides background on the phase 1/2 study of BMS-986158, presents initial efficacy and safety data from the study, and discusses her hope that novel combination regimens like these could achieve the challenging goal of disease modification in myelofibrosis in the future. ....

Haifa Kathrin Al Ali , University Hospital Of Halle Saale , Krukenberg Cancer Center , Translational Oncology , University Hospital , Bms 986158 , Bet Inhibitor , Phase 1 2 Ca011 023 Trial Nct04817007 ,

Dr Al-Ali on the Safety and Efficacy of BMS-986158 Plus Ruxolitinib or Fedratinib in Myelofibrosis

Haifa Kathrin Al-Ali, MD, discusses the safety and efficacy findings from the dose-escalation portion of the phase 1/2 CA011-023 trial of BMS-986158 in combination with ruxolitinib or fedratinib in patients with intermediate- or high-risk myelofibrosis. ....

Haifa Kathrin Al Ali , University Hospital Of Halle Saale , Krukenberg Cancer Center , Translational Oncology , University Hospital ,