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Canada invests $15M in first-of-its-kind pan-Canadian genome library

Today at the McGill Genome Centre, the Honourable Mark Holland, Minister of Health, announced a $15M investment over five years to create a Pan-Canadian Genome Library (PCGL), which will allow for easier sharing of genomic data across the country, and aid in the development of a national strategy to capture, store and access Canadian data in an equitable, secure, and sustainable manner. The funding comes from the Canadian Institutes of Health Research and builds on investments from the Government of Canada’s Drugs for Rare Diseases Strategy. ....

British Columbia , Martha Crago , Mark Holland , Guillaume Bourque , Montreal Mcgill University , Mcgill University Health Centre , University Health Network Toronto , Guillaume Bourque Department Of Human Genetics , Sinai Health System Toronto , Canadian Genome Library , Canadian Institutes Of Health Research , Vancouver Genome Sciences Centre , Canadian Genome Library Is Indigenous , University Of Victoria , York University , Genome Library , Mcgill Genome Centre , Ontario Institute For Cancer Research , Honourable Mark Holland , Pan Canadian Genome Library , Canadian Institutes , Health Research , Rare Diseases , Indigenous Peoples , Silent Genome Project , Mcgill University ,

Genome that includes more ethnicities could lead to better diagnosis, treatment

Genome that includes more ethnicities could lead to better diagnosis, treatment
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United States , Philip Awadalla , Guillaume Bourque , Gagan Gupta , Toronto Metropolitan University , Human Pangenome Reference Consortium , Mcgill University , Ontario Institute For Cancer Research , Ontario Institute ,

Moving towards a more inclusive approach to medicine: Release of pangenome representing wide diversity of individuals ushers in new understanding of human biology and disease

Moving towards a more inclusive approach to medicine: Release of pangenome representing wide diversity of individuals ushers in new understanding of human biology and disease
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Cristian Groza , Guillaume Bourque , Department Of Human Genetics At Mcgill University , Mcgill Genome Center , Human Genetics , Mcgill University , Mcgill Genome , Cell Genomics ,

Moving towards a more inclusive approach to m

The first human genome, which has served as the reference until now, was released approximately 20 years ago. It was a landmark accomplishment that had a huge impact on biomedical research and changed the way scientists study human biology. But it was based on just a few individuals and did not capture the full genetic diversity of the human population. “Since this reference has been at the core of most genomic analysis, it leads to a bias and we might miss important things happening in regions of the human genome that are not present in the reference,” says Guillaume Bourque, a professor in the Department of Human Genetics at McGill University and the Director of Bioinformatics at the McGill Genome Center. He is among a large group of scientists who have recently published an article in Nature about the first generation of a new type of reference genome, called a pangenome, that represents 47 individuals that are as genetically diverse as possible, from Africa, Asia, and the Cari ....

Cristian Groza , Guillaume Bourque , Department Of Human Genetics At Mcgill University , Mcgill University , Human Genetics , Mcgill Genome , Cell Genomics ,

A multiomics approach provides insights into flu severity

Researchers were able to identify changes in the accessibility (that is, the readability ) of transposable elements. To do this, the researchers used an approach combining various sets of multiomics data, which characterize and quantify collections of biomolecules in cells or organisms. One was the transcriptome, which consists of all copies of RNA transcribed from DNA in the cell. The other was the epigenome, which is the collection of chemical changes to DNA that modify gene expression. An advantage of this multiomics approach is that they were able to identify families of transposable elements with changes in accessibility, which would have likely been missed by previous approaches. ....

Xun Chen , Guillaume Bourque , Kyoto University , Mcgill University , University Of Chicago , Cell Genomics ,