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Frontiers | Concurrent Newborn Hearing and Genetic Screening in a Multi-Ethnic Population in South China

Hearing loss is a common sensory deficit in humans with intricate genomic landscape and mutational signature. Approximately 1 - 3 out of 1,000 newborns have hearing loss and up to 60% of these cases have a genetic etiology. In this study, we conducted the concurrent newborn hearing and genetic screening in 20 mutations in GJB2, GJB3, SLC26A4 and MT-RNR1 for 9,506 normal newborns (4,977 [52.4%] males) from 22 ethnic population in South China. A total of 1,079 (11.4%) newborns failed to pass the initial hearing screening, 160 (23.9%) infants failed to pass the re-screening, and 128 (1.4%) infants presented the diagnostic hearing loss. For the genetic screening, 220 (2.3%) newborns presented at least one of the screened mutations were more likely to fail the hearing screening and have diagnostic hearing loss than mutation negative newborns. In comparison of the differences of distribution of mutations, we did not identify any significant difference in the prevalence of screened mutations ....

United States , Eteläuomen Läi , South Korea , J Pediatr Otorhinolaryngol , Qixuan Wang , Ann Otol Rhinol Laryngol , Zhiwu Huang , Shanghai Jiao Tong University School Of Medicine , Zeesan Biological Technology Co Ltd , Child Health Care Hospital , Genome Reference Consortium Human , Human Genome Variation Society , Ethics Committee Of Liuzhou Maternal , Association For Molecular Pathology , Genetic Screening , Health Research , Child Health Hospital , American College Of Medical Genetics , Western Europeans , Southeast Asia , Liuzhou Maternal , Ethics Committee , Genetic Testing Kit , Hereditary Deafness , American College , Medical Genetics ,

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一、误失古剑
古剑不一定都是名剑,尽管该案被窃的这把古剑系西晋时期大名鼎鼎、名留青史的陆机的遗剑,但史籍中记载了陆机其人其事,却并未对其这把佩剑做过记录。如果一定要说该剑既是古剑又是名剑,那就要往陆机身上扯了。
陆机,字士衡,别名平原,籍贯吴郡吴县(今江苏省苏州市)。他出身于三国时代吴国的一个“高干”家庭,其祖父陆逊是三国时期著名的军事家,其父亲陆抗也是吴国名将。陆逊、陆抗父子当时被视为吴国的中流砥柱,朝野将其并称为“逊抗”。到了陆机这一代,他的战功虽跟上两代没法儿比,但人气却是超过了祖父陆逊和父亲陆抗。他在东吴时期就已是一位文武双全的全能超人,武方面,他是东吴牙门将。牙门将在有敌来犯时,必须亲率士兵奋勇与敌人作战。由此可见,陆机任牙门将之职,不但得有� ....

Hong Kong , United Kingdom , Khas Land , Liu Yang , South Korea , King Sima , Guo Shu , Guo Simon , King Yanqing , Liuaq Xu , Gordon Dragon , King Sima Ying , Nanning Starsky , Wuzhou Guilin Bose , Xu Yan , Pingliang Jun , Minga Guangxi , Kang Simon , Guangxi Nanning , City Office Branch , Ita City Department Of Cultural Affairs , Guo Health James , Shanghai Museum , Nanning Public Security Bureau To City Office , Heritage Management Department , Ministry Of Culture Country Cultural Heritage ,