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April 12, 2021 A new gene silencing tool allows scientists to switch genes on and off without altering genetic sequences. The tool, described in a paper published in
Cell on April 9, uses a modified CRISPR-Cas9 system to introduce reversible epigenetic changes that control gene expression.
The classic CRISPR-Cas9 system led to an explosion in gene editing studies since it was first developed almost a decade ago. It became quickly popular thanks to its ease of use compared to previous gene editing methods.
CRISPR-Cas9 uses guide RNA to chaperone the Cas9 nuclease to a particular site in the DNA and create a double-strand break. By adding a specially designed short sequence of DNA, scientists can introduce permanent genetic changes to the cell. This oligonucleotide is used as a template by the cell when repairing the double-strand break, incorporating the sequence into the cell s genome. However, this approach can cause unintended genetic changes. ....

United States , San Francisco , Luke Gilbert , Jonathan Weissman , University Of California , Jennifer Cook Chrysos Whitehead Institute For Biomedical Research , Massachusetts Institute Of Technology , Massachusetts Institute , Whitehead Institute , Crispr Cas9 , Gene Editing Tools , Guide Rna , Epigenetic Changes , Gene Silencing , Transcriptional Repressor Proteins , Transcriptional Activator Domains , Fusion Proteins , Cas9 Proteins , ஒன்றுபட்டது மாநிலங்களில் , சான் பிரான்சிஸ்கோ , லூக் கில்பர்ட் , ஜொனாதன் வெயிஸ்மேன் , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா , மாசசூசெட்ஸ் நிறுவனம் ஆஃப் தொழில்நுட்பம் , மாசசூசெட்ஸ் நிறுவனம் , வைட்ஹெட் நிறுவனம் ,