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IMAGE:  These results suggest that the cyclin D2-cardiomyocyte transplantation may be a potential therapeutic strategy for the repair of infarcted hearts, said study leader Jianyi Jay Zhang, M.D., Ph.D., the chair.
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Credit: UAB
BIRMINGHAM, Ala. - In a large-animal study, researchers have shown that heart attack recovery is aided by injection of heart muscle cells derived from human induced pluripotent stem cell line, or hiPSCs, that overexpress cyclin D2. This research, published in the journal
Circulation, used a pig model of heart attacks, which more closely resembles the human heart in size and physiology, and thus has higher clinical relevance to human disease, compared to studies in mice. ....

United States , Vahid Serpooshan , Yuxin Chu , Gregoryp Walcott , Jianyi Jay Zhang , Yuhua Wei , Antonv Borovjagin , Meng Zhao , Yuji Nakada , Wuqiang Zhu , Thanh Nguyen , Division Of Cardiovascular Disease , School Of Medicine , Emory University , National Institutes Of Health , Department Of Biomedical Engineering , Georgia Institute Of Technology , Department Of Cardiovascular Diseases , University Of Alabama At Birmingham , School Of Engineering , Informatics Institute , Department Of Medicine , Biomedical Engineering , Weihua Bian , Min Xie , Cardiovascular Disease ,