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New Study Provides Clues to Decades-Old Mystery About Cell Movement


Provenzano Lab, University of Minnesota
Cancer cells (shown in green) often align their movement to collagen fibers (shown in white). Understanding how cells move is key to preventing cancer spread throughout the body.
Tranquillo group, University of Minnesota
Human skin cells entrapped in an aligned fibrin gel exhibit contact guidance by orienting themselves along the aligned protein fibers in tissues.
Tranquillo group, University of Minnesota
A University of Minnesota study provides the first proof of a 1982 theory that the mechanical resistance (the stiffness of the fibers) plays a key role in controlling the movement of cells. The discovery could have a major impact on regenerative medicine and cancer research. ....

United States , University Of California Los Angeles , City Of , United Kingdom , Victork Lai , Greeshma Thrivikraman , Connie Wang , Alicja Jagie , Alexj Levine , Sandral Johnson , Alexander Nelson , Los Angeles , Robert Tranquillo , Billianne Schultz , Mark Keating , Elliotl Botvinick , University Of California , University Of Minnesota Twin Cities , Department Of Chemical Engineering , National Institutes Of Health , Department Of Biomedical Engineering , National Science Foundation , Mcknight University Professor , Graham Dunn At King College , University Of Minnesota , Minnesota Twin Cities ,

Lab-created heart valves can grow with the recipient


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VIDEO: This video shows a University of Minnesota lab-created tri-tube heart valve being tested under heart condition for function in ViVitro pulse duplicator system.
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Credit: Syedain, et al., Tranquillo Lab, University of Minnesota; Science Translational Medicine: https://z.umn.edu/pediatricheartvalves
A groundbreaking new study led by University of Minnesota Twin Cities researchers from both the College of Science and Engineering and the Medical School shows for the first time that lab-created heart valves implanted in young lambs for a year were capable of growth within the recipient. The valves also showed reduced calcification and improved blood flow function compared to animal-derived valves currently used when tested in the same growing lamb model. ....

United States , Richard Bianco , Greeshma Thrivikraman , Johnp Carney , Ryanc Hill , Jirong Li , Zeeshan Syedain , Sandral Johnson , Matthew Lahti , Robert Tranquillo , James Berry , Vascudyne Inc , University Of Minnesota Twin Cities , National Institutes Of Health , Department Of Chemical Engineering , College Of Science , Drug Administration , American Association For The Advancement Of Science , University Of Minnesota , Minnesota Twin Cities , Medical School , Science Translational Medicine , American Association , Biomedical Engineering , Chemical Engineering , Bee Haynie ,