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Novel solution for deadly allergies
Researchers may have found the key to preventing killer allergic reactions – embedded in our own immune systems.
Illustration of the antigen binding fragment (Fab) of a rheumatoid factor autoantibody bound to the tail, or Fc (fragment crystallisable), region of its target immunoglobulin G antibody. Credit: Mehau Kulyk / Science Photo Library / Getty Images.
Researchers at the Australian National University (ANU) have discovered a function in the immune system that could hold the key to treating allergic conditions like asthma and stop life-threatening anaphylaxis. The process is driven by a protein in the body called neuritin.
“We found this absolutely fascinating mechanism of our own bodies that stops the production of rogue antibodies that can cause either autoimmunity or allergies,” says ANU’s Professor Carola Vinuesa, a senior author of the study.
AustraliaAustraliansAustralianPaula-gonzalez-figueroaCarola-vinuesaJamie-kidstonAustralian-national-universityGonzalez-figueroaஆஸ்திரேலியாஆஸ்திரேலியர்கள்ஆஸ்திரேலியபால-கோன்சலஸ்-ஃபிகேரோவScientists Find a Natural Protein That Stops Allergies And Autoimmune Conditions
11 MARCH 2021
For the millions of us plagued by hypersensitive, overactive, or downright abusive immune systems, it can feel like you re constantly fighting your own physical self.
From incessant allergies to life-threatening anaphylaxis and debilitating autoimmune disease, the system that s supposed to be protecting us can be problematic when it goes wrong. Now, we might be closer to fixing these issues in an entirely new way.
Using transgenic mice and cultures of cells taken from human tonsils, researchers have now found evidence of how our bodies might defend against the mistakes that result in conditions such as asthma, food allergies, and lupus. They found a protein called neuritin, produced by immune cells. It acts a bit like an inbuilt, boss-level antihistamine.
AustraliaAustralianPaula-gonzalez-figueroaAustralian-national-universityCellsNeuritinImmuneAmp-quotAllergiesAuto-immuneMiceAntibodies