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Climbing a new path allows chemists to ascend cancer’s steepest research challengesThe cancer gene MYC drives unrestrained cancer cell growth, but has proved a difficult drug target. Nature-inspired compounds succeed by chopping up MYC’s RNA.A collab ....
In a new study, researchers show how a critical Lassa virus protein, called polymerase, drives infection by harnessing a cellular protein in human hosts. Their ....
Mutations to Dyrk1a gene lead to brain undergrowth; an existing drug rescues the condition in newborn mice
A genetic mutation linked to autism causes significant undergrowth of brain tissue. An existing medicine appears to rescue the condition in mouse studies. Damage to the autism-associated gene Dyrk1a, sets off a cascade of problems in developing mouse brains, resulting in abnormal growth-factor signaling, undergrowth of neurons, smaller-than-average brain size, and, eventually, autism-like behaviors, a new study from Scripps Research, Florida, finds. The study from neuroscientist Damon Page, PhD, describes a new mechanism underlying the brain undergrowth seen in individuals with Dyrk1a mutations. Page’s team used those insights to target the affected pathway with an existing medicine, a growth hormone. It restored normal brain growth in the Dyrk1a mutant mice, Page says. ....