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"Glymphatic System Dysfunction and Sleep Disturbance May Contribute to " by Andie Scott-Massey, Matthew K. Boag et al.

Parkinson’s disease (PD) is a multisystem alpha-synucleinopathic neurodegenerative disease and the most prevalent neurodegenerative disorder after Alzheimer’s disease with a high incidence rate in the elderly population. PD is highly multifactorial in etiology and has complex and wide-ranging pathogenic mechanisms. Environmental exposures and genetic predisposition are prominent risk factors. However, current evidence suggests that an intimate link may exist between the risk factor of sleep disturbance and PD pathogenesis. PD is characterized by the pathological hallmarks of alpha-synuclein aggregations and dopaminergic neuron degeneration in the substantia nigra. The loss of dopamine-producing neurons results in both motor and non-motor symptoms, most commonly, bradykinesia, tremor, rigidity, psychiatric disorders, sleep disorders and gastrointestinal problems. Factors that may exacerbate alpha-synuclein accumulation and dopamine neuron loss include neuroinflammation and glymphati ....

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Children with lymphatic disorder have higher risk of stillbirth, chronic disease: Study

South Australian researchers have identified a genetic mutation responsible for a lymphatic disorder that may be responsible for causing stillbirth or severe, chronic disease in affected children. ....

South Australia , Natasha Harvey , Hamish Scott , University Of South Australia Uni , Centre For Cancer Biology , South Australian , Science Translational , Cancer Biology , Professor Natasha Harvey , Professor Hamish Scott , Prof Harvey , Ews India ,