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Diverse Genome Sequences Provide a Powerful Tool for Studying Risk of Heart Disease

Study of millions of people from diverse ancestral groups substantially improves identification of genomic variants associated with blood lipid levels ....

Ann Arbor , United States , Cashell Jaquish , Cristen Willer , Charles Rotimi , Global Lipids Genetics Consortium , Division Of Cardiovascular Sciences , National Institutes Of Health , National Heart Lung , University Of Michigan , Extramural Research Program , National Human Genome Research Institute , Intramural Research Program , Blood Institute , National Heart , Global Lipids Genetics , National Institutes , East Asian , Africa America Diabetes Mellitus , Research Program , Cardiovascular Sciences ,

Diversity in genetic data improves the ability to predict high cholesterol risk

Including data from people of diverse ancestries substantially improves certain genetic risk predictions in all populations, according to a study that examined the genes responsible for regulating blood cholesterol levels. ....

United States , Tim Assimes , Cristen Willer , Charles Rotimi , Emily Henderson , Global Lipids Genetics Consortium , Million Veteran Program , National Human Genome Research Institute , Informatics Center , Stanford University School Of Medicine , University Of Michigan , African Americans , Stanford University School , Alto Epidemiology , National Human Genome Research ,

Genome study unlocks risk of heart disease | Daily Express Online - Sabah's Leading News Portal

Daily Express is the sister paper of Overseas Chinese Daily News (OCDN). It was founded by the late Tan Sri Yeh Pao Tzu and the first issue hit the streets on March 1, 1963. Published in trilingual ie English, Bahasa Malaysia and Kadazan, it is by far the largest circulation daily newspaper in Sabah. ....

Ann Arbor , United States , Cashell Jaquish , Cristen Willer , Charles Rotimi , Global Lipids Genetics Consortium , Division Of Cardiovascular Sciences , National Institute Of Health , National Institutes Of Health , Intramural Research Programme , National Heart Lung , University Of Michigan , National Human Genome Research Institute , Blood Institute , National Institute , Global Lipids Genetics , National Institutes , East Asian , Africa America Diabetes Mellitus , Research Programme , Cardiovascular Sciences ,

Diverse Ancestries Yield More Predictive Genetic Risk Scores for Heart Disease

A genome-wide association study (GWAS) on 120 primary studies including 1.65 million participants including nearly 350,000 participants from non-European ancestries, shows including participants of diverse ancestries facilitates the identification of genomic variants that are more strongly associated with cardiovascular diseases. The authors noted, trans-ancestry GWAS will help identify effector genes and allow for accelerated biological insight and identification of potential drug targets. ....

Ann Arbor , United States , Cashell Jaquish , Cristen Willer , Amy Bentley , Charles Rotimi , Global Lipids Genetics Consortium , University Of Michigan , Research On Genomics , Global Health , National Human Genome Research Institute , Blood Institute , Intramural Research Program , National Heart , East Asian , Africa America Diabetes Mellitus , Research Program ,

Diverse genome sequences provide a powerful tool for studying risk of heart disease

In a large-scale study of people from diverse ancestries, researchers narrowed down the number of genomic variants that are strongly associated with blood lipid levels and generated a polygenic risk score to predict elevated low-density lipoprotein cholesterol levels, a major risk factor for heart disease. ....

Ann Arbor , United States , Harry Wedel , Cashell Jaquish , Cristen Willer , Charles Rotimi , Global Lipids Genetics Consortium , Division Of Cardiovascular Sciences , National Institutes Of Health , National Heart Lung , University Of Michigan , National Human Genome Research Institute , Intramural Research Program , Blood Institute , National Heart , Global Lipids Genetics , National Institutes , East Asian , Africa America Diabetes Mellitus , Research Program , Cardiovascular Sciences ,