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Time to Broaden Aneurysm Warnings for Fluoroquinolones?


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The link between fluoroquinolone antibiotics and aortic aneurysm (AA) was further strengthened by analysis of a U.S. commercial claims database.
Incidence of AA formation or dissection reached 7.5 per 10,000 prescription fills for fluoroquinolones at 90 days compared with 4.6 per 10,000 fills for comparator antibiotics (HR 1.20, 95% CI 1.17-1.24), according to Melina Kibbe, MD, and colleagues of the University of North Carolina at Chapel Hill. The study was published online in
JAMA Surgery, where Kibbe is an editor.
Patients filling prescriptions for these medications were also more likely to undergo aneurysm repair (HR 1.88 vs other antibiotics, 95% CI 1.44-2.46).
The study suggests fluoroquinolone use should be pursued with caution in all adults, not just in high-risk individuals as recommended by the current FDA black box warning, Kibbe s group wrote. ....

Melina Kibbe , Nicole Lou , Amanda Filiberto , Gilbert Upchurch Jr , University Of North Carolina At Chapel Hill , University Of Florida , North Carolina , Gilbert Upchurch , Event Reporting System , Medpage Today , மெலினா கிப்பே , நிக்கோல் லூ , அமண்டா பிலிபேர்தோ , கில்பர்ட் உப்சூர்ச் ஜூனியர் , பல்கலைக்கழகம் ஆஃப் வடக்கு கரோலினா இல் தேவாலயம் மலை , பல்கலைக்கழகம் ஆஃப் புளோரிடா , வடக்கு கரோலினா , கில்பர்ட் உப்சூர்ச் , நிகழ்வு புகாரளித்தல் அமைப்பு ,