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The brain cells you haven't heard about

Baljit Khakh will discuss the long-overlooked role of astrocytes in health and disease during his Faculty Research Lecture on April 19. ....

Tom Vondriska , Geoffrey Burnstock , Henryh Dale , Baljit Khakh , David Geffen School Of Medicine , University College London , Faculty Research On , Physiology Outreach Program , Faculty Research , Sir Henry , Outreach Program , David Geffen School , Professor Geoffrey Burnstock , Faculty News , Campus Events , Biological Sciences ,

"P2X receptors: Insights from the study of the domestic dog" by Ronald Sluyter, Reece A. Sophocleous et al.

Fifty years ago, the late Geoffrey Burnstock described the concept of purinergic nerves and transmission bringing into existence the broader concepts of purinergic signaling including P2X receptors. These receptors are trimeric ligand-gated cation channels activated by extracellular adenosine 5′-triphosphate (ATP). P2X receptors have important roles in health and disease and continue to gain interest as potential therapeutic targets in inflammatory, neurological, cardiovascular and many other disorders including cancer. Current understanding of P2X receptors has largely arisen from the study of these receptors in humans and rodents, but additional insights have been obtained from the study of P2X receptors in the domestic dog, Canis familiaris. This review article will briefly introduce purinergic signaling and P2X receptors, before detailing the pharmacological profiles of the two recombinant canine P2X receptors studied to date, P2X7 and P2X4. The article will then describe the cur ....

Geoffrey Burnstock , Companion Animal , Xtracellular Adenosine 5 Triphosphate , Igand Gated Ion Channel , Urinergic Receptor , Urinergic Signaling ,

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More Fever Swamp - LewRockwell LewRockwell.com
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