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Down Syndrome Memory Issues Tied to Genome Dark Matter

Down Syndrome Memory Issues Tied to Genome Dark Matter
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Mara Dierssen , Group Leader Of The Cellular Systems Neurobiology , Centre For Genomic Regulation , Genomic Regulation , Group Leader , Systems Neurobiology ,

Learning and memory problems in down syndrome

<p>The activity of Snhg11, a gene found in the 'dark matter' of the genome, is critical for the function and formation of neurons in the hippocampus, specifically in an area critical for learning and memory. Researchers have discovered the gene is less active in brains with three copies of chromosome 21, which causes Down syndrome, potentially contributing to the condition’s intellectual disabilities. The researchers plan on carrying out further research to discover the exact mechanisms of action involved, information that could open potential avenues for new therapeutic interventions. The findings were made by studying mouse models of Down syndrome and tissues provided by human donors. They are published today in Molecular Psychiatry.</p>
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Mara Dierssen , Method Of Research , Group Leader Of The Cellular Systems Neurobiology , Centre For Genomic Regulation , Genomic Regulation , Group Leader , Systems Neurobiology ,

Learning and memory problems in Down syndrome linked to alterations in genome's 'dark matter'

Learning and memory problems in Down syndrome linked to alterations in genome's 'dark matter'
medicalxpress.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from medicalxpress.com Daily Mail and Mail on Sunday newspapers.

Mara Dierssen , Group Leader Of The Cellular Systems Neurobiology , Centre For Genomic Regulation , Centro De Regulaci , Genomic Regulation , Group Leader , Systems Neurobiology , Molecular Psychiatry ,

Down Syndrome Memory and Learning Deficits Linked to Long Noncoding RNA

Down Syndrome Memory and Learning Deficits Linked to Long Noncoding RNA
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Comunidad Autonoma De Cataluna , Mara Dierssen , Centre For Genomic Regulation , Technology Centre For Genomic Regulation , Barcelona Institute Of Science , Barcelona Institute , Technology Centre , Genomic Regulation , Molecular Psychiatry ,

Learning and memory problems in down syndrome

Learning and memory problems in down syndrome
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Mara Dierssen , Method Of Research , Group Leader Of The Cellular Systems Neurobiology , Centre For Genomic Regulation , Genomic Regulation , Group Leader , Systems Neurobiology ,