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Frontiers | A Polygenic Score for Type 2 Diabetes Improves Risk Stratification Beyond Current Clinical Screening Factors in an Ancestrally Diverse Sample

A substantial proportion of the adult US population with type 2 diabetes (T2D) are undiagnosed, calling into question the comprehensiveness of current screening practices, which primarily rely on age, family history, and body mass index (BMI). We hypothesized that a polygenic score (PGS) may serve as a complementary tool to identify high-risk individuals. The T2D PGS maintained predictive utility after adjusting for family history and combining genetics with family history led to even more improved disease risk prediction. We observed that the PGS was meaningfully related to age of onset with implications for screening practices: there was a linear and statistically significant relationship between the PGS and T2D onset (-1.3 years per standard deviation of the PGS). Evaluation of U.S. Preventive Task Force and a simplified version of American Diabetes Association screening guidelines showed that addition of a screening criterion for those above the 90th percentile of the PGS provided ....

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Positive Results for Lipid inCode® in NHS Clinical Study

Lipid inCode® offers greater diagnostic information for hypercholesterolemia sufferers over current NHS standard. ....

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Positive Results for Lipid inCode® in NHS Clinical Study | Comunicados | Edición USA

Positive Results for Lipid inCode® in NHS Clinical Study | Comunicados | Edición USA
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Investegate |AIM Announcements | AIM: Schedule One Update

Investegate |AIM Announcements | AIM: Schedule One Update
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Investegate |GENinCode UK Ltd Announcements | GENinCode UK Ltd: Intention to float

Investegate |GENinCode UK Ltd Announcements | GENinCode UK Ltd: Intention to float
investegate.co.uk - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from investegate.co.uk Daily Mail and Mail on Sunday newspapers.

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