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Patchwork of Mutations Contribute to Bipolar Disorder

Patchwork of Mutations Contribute to Bipolar Disorder
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Patchwork of mutations contributing to bipola

Bipolar disorder (BD) is a serious psychiatric disorder affecting around 1% of the population worldwide. While medications are indispensable for these patients, they are not completely effective, and the underlying genetic architecture and pathogenesis of BD remain unresolved. Researchers from Japan have now used deep exome sequencing to show that mosaic variants/mutations found in genes related to developmental disorders and autism spectrum disease and in the mitochondrial tRNA region could be associated with BD. ....

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Researchers release first Japanese reference genome

The Japanese now have their own reference genome thanks to researchers at Tohoku University who completed and released the first Japanese reference genome (JG1). ....

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Constructing First Version of Japanese Reference Genome

Date Time
Constructing First Version of Japanese Reference Genome
The Japanese now have their own reference genome thanks to researchers at Tohoku University who completed and released the first Japanese reference genome (JG1).
Their study was published in the journal Nature Communications on January 11, 2021.
“JG1 can aid with the clinical sequence analysis of Japanese individuals with rare diseases as it eliminates the genomic differences from the international reference genome,” said Jun Takayama, co-author of the study.
Back in 2003, the Human Genome Project, through a gargantuan global effort, cracked the code of life and mapped all the genes of the human genome. ....

Japan General , Chinatsu Gocho , Kenji Yano , Satoshi Makino , Akihito Otsuki , Yasunobu Okamura , Jun Yasuda , Shigeo Kure , Atsuo Kikuchi , Jun Takayama , Gen Tamiya , Kengo Kinoshita , Fumiki Katsuoka , Shu Tadaka , Sachiyo Sugimoto , Junko Kawashima , Masayuki Yamamoto , Takamitsu Funayama , Mika Sakurai Yageta , Nature Communications , Miyagi Cancer Research Institute , Tohoku University Medical Megabank Organization Tommo , Research Center , Japanese Reference Genome Assembly , Tohoku University School Of Medicine , Nature Communications On ,

Constructing the First Version of the Japanese Reference Genome

Tohoku University
The Japanese now have their own reference genome thanks to researchers at Tohoku University who completed and released the first Japanese reference genome (JG1).
Their study was published in the journal Nature Communications on January 11, 2021.
JG1 can aid with the clinical sequence analysis of Japanese individuals with rare diseases as it eliminates the genomic differences from the international reference genome, said Jun Takayama, co-author of the study.
Back in 2003, the Human Genome Project, through a gargantuan global effort, cracked the code of life and mapped all the genes of the human genome.
Since then, more accurate versions of the human reference genome have been realized. Aiding this has been the advancement in next-generation sequencing technologies that allow for short read of approximately several hundred bases in a massively parallel way, reducing the costs and time to sequence DNA and RNA. ....

Japan General , Gen Tamiya , Jun Takayama , Miyagi Cancer Research Institute , Tohoku University Medical Megabank Organization Tommo , Research Center , Tohoku University Medical Megabank Organization , Japanese Reference Genome Assembly , Tohoku University School Of Medicine , Nature Communications On , School Of Information Sciences , Tohoku University , Department Of Public Relations , Nature Communications , Human Genome Project , Tohoku Medical Megabank Organization , Advanced Research Center , Next Generation Medicine , Tohoku University School , Information Sciences , Public Relations , ஜப்பான் ஜநரல் , கேன் தமியா , ஜூன் தக்காயமா , மியையேஜை புற்றுநோய் ஆராய்ச்சி நிறுவனம் , ஆராய்ச்சி மையம் ,