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Arvinas and Pfizer Announce Updated Clinical Data from Phase 1b Trial of Vepdegestrant in Combination with Palbociclib (IBRANCE®)

Arvinas and Pfizer Announce Updated Clinical Data from Phase 1b Trial of Vepdegestrant in Combination with Palbociclib (IBRANCE®)
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United States , New York , Jeff Boyle , Roger Dansey , Noah Berkowitz , Kathleen Murphy , Breast Cancer Annual Congress , Sarah Cannon Research Institute In Nashville , Exchange Commission , Breast Cancer Research , Arvinas Inc , Pfizer Inc , Drug Administration , Breast Cancer Research Executive Committee , European Society For Medical Oncology , Pfizer Announce Updated Clinical Data , San Antonio Breast Cancer Symposium , Medical Oncology , Breast Cancer Annual , Chief Medical Officer , Chief Development Officer , Erika Hamilton , Director Breast Cancer Research , Executive Chair , Sarah Cannon Research Institute , Palbociclib Phase ,

Arvinas and Pfizer Announce Updated Clinical Data from Phase 1b Trial of Vepdegestrant in Combination with Palbociclib (IBRANCE)

Arvinas and Pfizer Announce Updated Clinical Data from Phase 1b Trial of Vepdegestrant in Combination with Palbociclib (IBRANCE)
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United States , New York , Kathleen Murphy , Roger Dansey , Jeff Boyle , Noah Berkowitz , Exchange Commission , Breast Cancer Research Executive Committee , Drug Administration , Breast Cancer Research , Breast Cancer Annual Congress , European Society For Medical Oncology , Arvinas Inc , Sarah Cannon Research Institute In Nashville , Pfizer Inc , San Antonio Breast Cancer Symposium , Medical Oncology , Breast Cancer Annual , Chief Medical Officer , Chief Development Officer , Erika Hamilton , Director Breast Cancer Research , Executive Chair , Sarah Cannon , Research Institute , Palbociclib Phase ,

Similarity of Polymer Packing in Melts Is Dictated by N̅

Similarity of Polymer Packing in Melts Is Dictated by N̅
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France General , Pays De La Loire , United Kingdom , Scott Milner , Butterworth Heinemann , Frank Bates , David Morse , Jian Qin , Monte Carlo , Pennsylvania State University , Cornell University , University Of Minnesota , Department Of Chemical Engineering At Stanford University , Oxford University , Stanford University , Cambridge University , Ww Polymeric Liquids Networks , University Of Chicago , Oxford University Press , Cambridge University Press , Tsinghua University , Assistant Professor , Chemical Engineering , Materials Science , Juan De Pablo , Terman Faculty Fellow ,

Neuronal dynamics direct cerebrospinal fluid perfusion and brain clearance

The accumulation of metabolic waste is a leading cause of numerous neurological disorders, yet we still have only limited knowledge of how the brain performs self-cleansing. Here we demonstrate that neural networks synchronize individual action potentials to create large-amplitude, rhythmic and self-perpetuating ionic waves in the interstitial fluid of the brain. These waves are a plausible mechanism to explain the correlated potentiation of the glymphatic flow1,2 through the brain parenchyma. Chemogenetic flattening of these high-energy ionic waves largely impeded cerebrospinal fluid infiltration into and clearance of molecules from the brain parenchyma. Notably, synthesized waves generated through transcranial optogenetic stimulation substantially potentiated cerebrospinal fluid-to-interstitial fluid perfusion. Our study demonstrates that neurons serve as master organizers for brain clearance. This fundamental principle introduces a new theoretical framework for the functioning of ma ....

South Korea , Ruyter Van Steveninck , Ioi Properties , Garland Science , Academic Press , Neural Data ,

Arvinas and Pfizer Announce Interim Data from Phase 1b Trial of Vepdegestrant in Combination with Palbociclib (IBRANCE®) and Plans to Expand Vepdegestrant Development Program

Arvinas and Pfizer Announce Interim Data from Phase 1b Trial of Vepdegestrant in Combination with Palbociclib (IBRANCE®) and Plans to Expand Vepdegestrant Development Program
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United States , New York , Jeff Boyle , Kirsten Owens , John Houston , Adam Schayowitz , Exchange Commission , Arvinas Inc , Arvinas Communications , Pfizer Inc , Antonio Breast Cancer Symposium , Palbociclib Phase , Erika Hamilton , Breast Cancer Research , Sarah Cannon Research Institute , Abstracts Presented , Forward Looking Statementsthis , Private Securities Litigation Reform Act , Annual Report , Pfizer Oncologyat Oncology , Breakthroughs That Change Patient Livesat Pfizer , Pfizer News , Disclosure Notice , Looking Information , Factors That May Affect Future , Arvinas Investor Relations ,