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June 14, 2021 PET imaging with a gallium-68 (Ga-68)-labeled fibroblast activation protein inhibitor (FAPI) shows promise as an effective way to identify and monitor pulmonary fibrosis, according to animal study findings presented at the virtual 2021 Society of Nuclear Medicine and Molecular Imaging (SNMMI) annual meeting. The technique could add molecular imaging to the lung disease toolbox and perhaps reduce the number of biopsies, said study lead author Carolina de Aguiar Ferreira, PhD, of the University of Wisconsin-Madison in a statement released June 12 by the SNMMI. Further validation of [PET/CT with gallium-68] for the detection and monitoring of pulmonary fibrosis would make this molecular imaging tool the first technique for early, direct, and noninvasive detection of disease, she said. It would also provide an opportunity for molecular imaging to reduce the frequency of lung biopsies, which carry their own inherent risks. ....
Abstract Purpose: Functional lung mapping from Ga -ventilation/perfusion (V/Q) PET/CT, which has been shown to correlate with pulmonary function tests (PFTs), may be beneficial in a number of clinical applications where sparing regions of high lung function is of interest. Regions of clumping in the proximal airways in patients with airways disease can result in areas of focal intense activity and artefact in ventilation imaging. These artefacts may even shine through to subsequent perfusion images and create a challenge for quantitative analysis of PET imaging. We aimed to develop an automated algorithm that interprets the uptake histogram of PET images to calculate a peak uptake value more representative of the global lung volume. Methods: Sixty-six patients recruited from a prospective clinical trial underwent both V/Q PET/CT imaging and PFT analysis before treatment. PET images were normalised using an iterative histogram analysis technique to account for tracer hotspots p ....
In a direct comparison with gallium-68 (Ga-68) prostate-specific membrane antigen (PSMA) PET/CT, MR imaging with a ferumoxtran-10 nanoparticle contrast agent (nano-MRI) identified significantly more suspected serious lymph nodes, as well as nodes that were significantly smaller. At the same time, the two approaches were fairly complementary, as they both discovered some lymph nodes the other modality missed. Although there is no reference standard in this study, the main results mentioned above provide insight into the complementary performance of both modalities by identifying aspects where they agree and disagree, wrote the authors led by Dr. Melline Schilham from Radboud University Medical Centre, Nijmegen, the Netherlands. Such results allow the definition of future areas of research that need to be addressed in order to define the optimal imaging strategy for prostate cancer patients. ....