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Cell envelope and stress-responsive pathways underlie an evolved oleaginous Rhodotorula toruloides strain multi-stress tolerance | Biotechnology for Biofuels and Bioproducts

The red oleaginous yeast Rhodotorula toruloides is a promising cell factory to produce microbial oils and carotenoids from lignocellulosic hydrolysates (LCH). A multi-stress tolerant strain towards four major inhibitory compounds present in LCH and methanol, was derived in our laboratory from strain IST536 (PYCC 5615) through adaptive laboratory evolution (ALE) under methanol and high glycerol selective pressure. Comparative genomic analysis suggested the reduction of the original strain ploidy from triploid to diploid, the occurrence of 21,489 mutations, and 242 genes displaying copy number variants in the evolved strain. Transcriptomic analysis identified 634 genes with altered transcript levels (465 up, 178 down) in the multi-stress tolerant strain. Genes associated with cell surface biogenesis, integrity, and remodelling and involved in stress-responsive pathways exhibit the most substantial alterations at the genome and transcriptome levels. Guided by the suggested stress response ....

Atpase Neo , Genome Institute , Additional File , Supplementary Table , Differentially Expressed Genes , Joint Genome Institute , Eukaryotic Orthologous Groups , Functional Enrichment Analysis ,

Network Pharmacological Mechanism Research of Herba Drynariae Rhizoma-Epimedii Folium in Treating Osteoarthritis

Network Pharmacological Mechanism Research of Herba Drynariae Rhizoma-Epimedii Folium in Treating Osteoarthritis
Zonghui Dai
2Department of Orthopedics, Jingzhou Central Hospital, Second Clinical Medical Hospital, Yangtze University, Jingzhou, China
Copyright © 2021 by author(s) and Scientific Research Publishing Inc.
This work is licensed under the Creative Commons Attribution International License (CC BY 4.0).
ABSTRACT
Objective: To investigate the potential mechanism of Drynariae Rhizoma-Epimedii Folium in the treatment of osteoarthritis (OA) based on network pharmacology. Methods: The potential active constituents and targets of Drynariae Rhizoma-Epimedii Folium were screened through the traditional Chinese medicine (TCM) systems pharmacology database and analysis platform (TCMSP). Genecards database is used to find relevant targets of OA. The targets of “Drynariae Rhizoma-Epimedii Folium” were mapped to the targets of OA, and used Cytoscape softwa ....

China General , Drynariae Rhizoma , Drynariae Rhizoma Epimedii , Network Pharmacology , Protein Interaction Network Of Drynariae Rhizoma Epimedii Folium , Research Ideas , Drynariae Rhizoma Epimedii Folium , Epimedii Folium , Traditional Chinese , Drynaria Fortunei , Active Ingredient , Target Prediction , Chinese Medicine Systems Pharmacology Database , Analysis Platform , Therapeutic Targets , Protein Interaction Network , Functional Enrichment Analysis , Kyoto Encyclopedia , Pathway Enrichment , Joint Foundation , Health Commission , Hubei Province , Network Pharmacological Mechanism Research , Herba Drynariae Rhizoma Epimedii Folium , Yangtze Medicine , சீனா ஜநரல் ,