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Food additive emulsifiers and cancer risk: Results from the French prospective NutriNet-Santé cohort

Author summary Why was this study done? Emulsifiers are widely used food additives in industrially processed foods to improve texture and enhance shelf-life. Experimental in vivo/in vitro research as well as a pilot clinical trial on healthy individuals suggests deleterious effects of food additive emulsifier intake on the intestinal microbiota, metabolome, host inflammation, and susceptibility to carcinogenesis. To our knowledge, due to challenges to accurately estimate the exposure to food additive emulsifiers through diet, so far there was no available epidemiological evidence from prospective cohorts on food additive emulsifier intakes in relation to cancer risk. What did the researchers do and find? This study assessed quantitative exposures to a wide range of food additive emulsifiers in a large prospective cohort of adults. Higher intakes of mono- and diglycerides of fatty acids (FAs) (E471), total carrageenans (E407, E407a), and carrageenan (E407) were associated with hig ....

France General , United Kingdom , United States , Porcher Universit , Hong Van Duong , Merveille Kouam , Laurent Bourhis , Selleml Srour , Nathalie Arnault , Fumiaki Imamura , Maria Gomes , Julien Allegre , Paola Yvroud , Nicolas Dechamp , Aladi Timera , Jagatjit Mohinder , Idex Universit , Multivariable Cox , European Union Horizon , European Food Safety Authority , University Sorbonne Paris Nord , Conservatoire National Des Arts , Norwegian Breast Cancer Screening Program , French Food Safety Agency , Bettencourt Schueller Foundation Research Prize , Institut National De La Recherche ,

Domain Therapeutics Awarded Hospital-University Research in Health (RHU) SPRINT Consortium Grant to Progress Its Proprietary CCR8 Antibody Candidate to the Clinic

Domain Therapeutics Awarded Hospital-University Research in Health (RHU) SPRINT Consortium Grant to Progress Its Proprietary CCR8 Antibody Candidate to the Clinic
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France General , Namrata Taak , Stephan Schann , Anthony Johnson , Amber Fennell , French National Cancer Institute Inca , Research At Domain Therapeutics , University Research In Health , French Study Group On Cutaneous Lymphomas , Paris Cit , Hospital University Research , Agence Nationale De La Recherche , Hospices Civils De Lyon , Domain Therapeutics , European Reference Network , Rare Hematological Diseases , French Study Group , Cutaneous Lymphomas , French National Cancer Institute , Saint Louis Hospital , Andrew Stern ,

Health Minister Marks National Childhood Cancer Awareness Month

Health Minister Marks National Childhood Cancer Awareness Month
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France General , Mark Holland , National Childhood Cancer Awareness Month , Cancer Research Society , Ontario Institute For Cancer Research , Canadian Pediatric Cancer Consortium , Terry Fox Research Institute , Canadian Institutes Of Health Research , International Childhood Cancer Data Partnership , Grant Program , French National Cancer Institute Inca , Canadian Cancer Society , Canadian Institutes , Health Research , Sick Children , First Nations , Project Grant , French National Cancer Institute , Paris Conference , Genome Canada , Ontario Institute , Cancer Research ,

Food additive emulsifiers and risk of cardiovascular disease in the NutriNet-Santé cohort: prospective cohort study

Objective To assess the associations between exposure to food additive emulsifiers and risk of cardiovascular disease (CVD).

Design Prospective cohort study.

Setting French NutriNet-Santé study, 2009-21.

Participants 95 442 adults (>18 years) without prevalent CVD who completed at least three 24 hour dietary records during the first two years of follow-up.

Main outcome measures Associations between intake of food additive emulsifiers (continuous (mg/day)) and risk of CVD, coronary heart disease, and cerebrovascular disease characterised using multivariable proportional hazard Cox models to compute hazard ratios for each additional standard deviation (SD) of emulsifier intake, along with 95% confidence intervals.

Results Mean age was 43.1 (SD 14.5) years, and 79.0% (n=75 390) of participants were women. During follow-up (median 7.4 years), 1995 incident CVD, 1044 coronary heart disease, and 974 cerebrovascular disease events were diagnosed. Hig ....

France General , United States , United Kingdom , Eteläuomen Läi , Nicolas Dechamp , Paola Yvroud , Aladi Timera , Jagatjit Mohinder , Maria Gomes , Nathalie Arnault , Rizvane Mougamadou , Mirette Foham , Dieta Mediterr , Idex Universit , Hong Van Duong , Laurent Bourhis , World Health Organization , Institut National De La Recherche , Bettencourt Schueller Foundation , European Food Safety Authority In Europe , European Union Horizon , University Sorbonne Paris Nord , French Medical Institute For Health , Linstitut National De La Sant , European Research Council , Council Of State No ,

CAR T cell therapy: study shows remote destruction of tumor cells

The aim of immunotherapy strategies is to use cells in the patient s own immune system to destroy tumor cells. CAR T cell therapy is an immunotherapy that is effective in treating blood cancer. Around 35,000 people are affected by blood cancer each year in France, with 1.24 million cases worldwide. ....

France General , Philippe Bousso , Institut Pasteur , Paris Public Hospital Network , European Research Council , French National Cancer Institute Inca , Immune Responses Unit , French National Cancer Institute , European Research ,