Many new drug candidates end up failing because they cause serious side effects in clinical trials even though lab tests involving cell cultures have been successful. This is a common occurrence if the cells used come from animal tissue, for example. Specially prepared cell cultures made from human tissue known as human induced pluripotent stem (hiPS) cells enable greater reliability in testing, thereby also increasing the chances that a drug will be approved. Fraunhofer researchers have developed innovative solutions for optimized production of cells in bioreactors and unique cryotechnologies. This is paving the way for efficient real-world use of these cell cultures in toxicity testing and drug discovery.
Bioreactor processes and cryotechnologies improve active ingredient tests using human cell cultures
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Global Ultrasound Systems Clinical Pipeline Research 2023: Stages of Development, Segments, Region and Countries, Regulatory Path and Competitive Landscape
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Prosthetic hand control significantly improved by ultrasonic sensors
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For anyone who has lost a hand, a functional prosthetic hand is of enormous benefit when it comes to everyday activities. So researchers at Fraunhofer are working as part of an EU research project to improve control of prosthetic hands down to individual fingers. Instead of conventional electrodes that detect nerve impulses in muscle tissue in the arm, these rely on ultrasonic sensors. This means commands can be executed with far greater accuracy and sensitivity. In the next stage, researchers want to make the design bidirectional, with the brain also receiving sensory stimuli from the prosthesis.