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An international study led by researchers from the Faculty of Pharmacy at the Complutense University of Madrid has identified a series of biosynthetic genes involved in the production of usnic acid in lichen, a compound showing antiviral, antioxidant, neuroprotective, antibacterial and anticancer activity.
Not all lichens composite organisms resulting from the symbiosis of fungi and green algae or cyanobacteria produce this compound, and this study, published in
Genome Biology and Evolution, has revealed why there is a loss of specific biosynthetic genes in non-producing species.
Identifying the genes involved in the biosynthesis of these compounds is essential for future studies that require their isolation and mass production; similarly, the genomic approach adopted in this study has helped us identify new biosynthetic genes (PKS) of as yet unknown compounds that may be of pharmacological interest , explained David Pizarro, the first author of the s ....

United States , Felix Grewe , David Pizarro , Pradeepk Divakar , Francesco Dal Grande , Pradeep Divakar , Helge Thorsten Lumbsch , Complutense University Of Madrid , Field Museum Of Natural History , Climate Research Centre In Frankfurt , Department Of Pharmacology , Complutense University , Genome Biology , Field Museum , Natural History , Senckenberg Biodiversity , Climate Research Centre , Ana Crespo , Helge Thorsten , Wide Analysis , Usnic Acid , ஒன்றுபட்டது மாநிலங்களில் , டேவிட் பிசாரோ , பிரான்செஸ்கோ பருப்பு கிராண்டே , ப்ரதீப் திவாகர் , புலம் அருங்காட்சியகம் ஆஃப் இயற்கை வரலாறு ,