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New technique reveals switches in RNA


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IMAGE: This is Dr. Danny Incarnato, a molecular geneticist at the University of Groningen, the Netherlands. In collaboration with colleagues from the University of Torino (Italy), his team developed a method.
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Credit: University of Groningen
Scientists at the University of Groningen (The Netherlands), in collaboration with colleagues from the University of Torino (Italy), have developed a method to visualize and quantify alternative structures of RNA molecules. These alternative RNA shapes can have important functional relevance in viruses and bacteria. The researchers used an algorithm to rapidly analyse large quantities of chemically modified RNA molecules and calculate how many differently folded conformations were present. This technique was used to identify a conserved structural switch in the RNA of the SARS-CoV-2 virus. The results of this analysis were published in the journal ....

Edoardo Morandi , Ilaria Manfredonia , Danny Incarnato , Lisam Simon , Francesca Anselmi , University Of Torino , University Of Groningen , Nature Methods , Salvatore Oliviero , Biomechanics Biophysics , Infectious Emerging Diseases , Pharmaceutical Science , எடொஅறுதோ மொராண்டி , பல்கலைக்கழகம் ஆஃப் டொரினோ , பல்கலைக்கழகம் ஆஃப் க்ராநிகந் , இயற்கை முறைகள் , பயோமெக்கானிக்ஸ் உயிர் இயற்பியல் , உயிர் வேதியியல் , தொற்று வளர்ந்து வருகிறது நோய்கள் , மருந்து அறிவியல் , உயிர் தகவலியல் ,