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For Andrea Shaw, the perimenopause came with a portfolio of symptoms, from urinary tract infections to heart palpitations. Hormone replacement therapy (HRT) helped, but not entirely. She says she was left with a long list of symptoms, including “brain fog, concentration, energy levels and low libido”. She adds: “The low mood, crying episodes, wanting to stay in my bedroom and not wanting to go out were crippling. I had turned into a person I no longer recognised and felt extremely lonely and sad ....