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Scientists compare DNA damaging properties of chemicals from vape products and cigarettes


Scientists compare DNA damaging properties of chemicals from vape products and cigarettes
Imperial Brands scientists have utilized Toxys ToxTracker suite of stem-cell based in-vitro assays, which provide mechanistic insight into the potential DNA damaging properties of chemicals, comparing vape e-liquid samples and their aerosols to combustible cigarette smoke.
Imperial scientists are the first to publish results using the ToxTracker system for the assessment of vape e-liquids and aerosols, and it forms part of the company s continuing research into the tobacco harm reduction potential of Next Generation Products (NGPs) such as vapes.
The assays help assess how product samples may impact cellular functioning across six reporter cell lines, picking up the tell-tale molecular signs of potential harm in the form of oxidative stress, DNA and protein damage, as well as activation of the p53 gene that has a role in cell cycle regulation and tumour suppression. ....

Toxy Toxtracker , Lukasz Czekala , Fiona Chapman , Emily Henderson , Next Generation Products , Senior Pre Clinical Toxicologist , Imperial Brands , Pre Clinical Toxicologist , Next Generation Product , Toxicity Testing , Tobacco Harm Reduction Science , Cell Line , Dna Damage , Next Generation , Oxidative Stress , பியோனா சாப்மேன் , எமிலி ஹென்டர்சன் , அடுத்தது ஜெநரேஶந் ப்ராடக்ட்ஸ் , ஏகாதிபத்தியம் பிராண்டுகள் , அடுத்தது ஜெநரேஶந் ப்ராடக்ட் , புகையிலை தீங்கு குறைப்பு அறிவியல் , செல் வரி , டீயெநே சேதம் , அடுத்தது ஜெநரேஶந் , மன அழுத்தம் ,

Vaping vs. smoking: Impact on cells compared


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IMAGE: Diagram showing the six reporter cells lines of the ToxTracker test, plus a wild type (wt) cell line used to visualise microscopic signs of DNA damage.
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Credit: Toxys
Imperial Brands scientists have utilised Toxys ToxTracker suite of stem-cell based in-vitro assays, which provide mechanistic insight into the potential DNA damaging properties of chemicals, comparing vape e-liquid samples and their aerosols to combustible cigarette smoke.
Imperial scientists are the first to publish results using the ToxTracker system for the assessment of vape e-liquids and aerosols, and it forms part of the company s continuing research into the tobacco harm reduction potential of Next Generation Products (NGPs) such as vapes. ....

Toxy Toxtracker , Lukasz Czekala , Fiona Chapman , Imperial Brands , Next Generation Products , Senior Pre Clinical Toxicologist , Pre Clinical Toxicologist , Next Generation Product , Toxicity Testing , Tobacco Harm Reduction Science , பியோனா சாப்மேன் , ஏகாதிபத்தியம் பிராண்டுகள் , அடுத்தது ஜெநரேஶந் ப்ராடக்ட்ஸ் , அடுத்தது ஜெநரேஶந் ப்ராடக்ட் , புகையிலை தீங்கு குறைப்பு அறிவியல் ,

Scientists compare harmful effects of vaping with smoking


Scientists compare harmful effects of vaping with smoking
ANI |
Updated: Apr 09, 2021 21:43 IST
Bristol [UK], April 9 (ANI): Scientists from the tobacco company Imperial Brands have utilised Toxys ToxTracker suite of stem-cell-based in-vitro assays that provide a mechanistic insight into the potential DNA damaging properties of chemicals and compared the vape e-liquid samples and their aerosols with combustible cigarette smoke.
Imperial scientists are the first to publish results using the ToxTracker system for the assessment of vape e-liquids and aerosols, and it forms part of the company s continuing research into the tobacco harm reduction potential of Next Generation Products (NGPs) such as vapes. ....

Toxy Toxtracker , Lukasz Czekala , Fiona Chapman , Imperial Brands , Next Generation Products , Senior Pre Clinical Toxicologist , Pre Clinical Toxicologist , Next Generation Product , Toxicity Testing , Tobacco Harm Reduction Science , பியோனா சாப்மேன் , ஏகாதிபத்தியம் பிராண்டுகள் , அடுத்தது ஜெநரேஶந் ப்ராடக்ட்ஸ் , அடுத்தது ஜெநரேஶந் ப்ராடக்ட் , புகையிலை தீங்கு குறைப்பு அறிவியல் ,