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Novel approach to multimodal aging clock for interpretable age prediction and target discovery

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 11, entitled, "Precious1GPT: multimodal transformer-based transfer learning for aging clock development and feature importance analysis for aging and age-related disease target discovery." ....

Alex Aliper , Denis Sidorenko , Aleksandr Kalashnikov , Ivanv Ozerov , Danielle Ellis , Alex Zhavoronkov , Stefan Pushkov , Vladimir Naumov , Diana Zagirova , Ekaterina Kozlova , Duen Leung , Viktoria Sarkisova , Feng Ren , Anatoly Urban , Geoffrey Ho Duen Leung , Hoi Wing Leung , Insilico Medicine ,

Insilico Medicine nominates pan-TEAD inhibitor as a potential solution for drug resistance in solid tumor patients

Insilico Medicine, a generative artificial intelligence (AI)-driven clinical-stage drug discovery company, today announced the nomination of ISM6331, a potential best-in-class pan-TEAD inhibitor, as a preclinical candidate compound (PCC) generated by Chemistry42, its proprietary generative chemistry-driven molecule design engine, targeting the Hippo pathway for the treatment of advanced solid tumors. ....

Alex Zhavoronkov , Feng Ren , Danielle Ellis , Chief Scientific Officer ,