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Medigene shares sag as it axes TCR-T blood cancer drug, with COVID-19 partly to blame

(Medigene)
German biotech Medigene saw its shares drag down 7% into the red Thursday after it decided to cull one of its T-cell receptor modified (TCR-T) cancer assets after delays by COVID-19 restrictions hampered its efforts.
The therapy, MDG1021, which targets the antigen HA-1, works as a TCR-T immunotherapy and was being tested in patients suffering from relapsed or persistent blood cancers after allogeneic (non-self) hematopoietic stem cell transplantation, an area with high unmet medical need.
It was originally licensed from the Leiden University Medical Center (LUMC) in the Netherlands at the end of 2018. But now the company, which is looking to focus on solid tumors, said the development program of the therapy “is to be discontinued.” ....

Kai Pinkernell , Syneos Health , Community Health Leaders , Leiden University Medical Center , Clinical Research , Clinical Trial Diversity , Four Part Webinar Series , Featuring Pharma , சமூக ஆரோக்கியம் தலைவர்கள் , மருத்துவ ஆராய்ச்சி , மருத்துவ சோதனை பன்முகத்தன்மை , நான்கு பகுதி வெபினார் தொடர் , இடம்பெறும் பார்மா ,

TALEN gene editing tool more efficient than CRISPR-Cas9 in compact DNA: study

Jan 28, 2021 10:10am
Scientists at the University of Illinois at Urbana-Champaign found that the gene editing tool TALEN is up to five times more efficient than CRISPR-Cas9 in parts of the genome called heterochromatin. (LionFive/Pixabay)
CRISPR-Cas9 has made waves in the biomedical world as a revolutionary gene editing tool, even garnering a 2020 Nobel Prize in chemistry. But it has its limitations.
A research team from the University of Illinois at Urbana-Champaign (UIUC) showed that another gene editing technique called TALEN is up to five times more efficient than CRISPR-Cas9 in a highly compact form of DNA called heterochromatin, according to results published in Nature Communications. ....

Syneos Health , Nature Communications , Community Health Leaders , Clinical Research , University Of Illinois At Urbana Champaign , Columbia University , Clinical Trial Diversity , Four Part Webinar Series , Featuring Pharma , இயற்கை தகவல்தொடர்புகள் , சமூக ஆரோக்கியம் தலைவர்கள் , மருத்துவ ஆராய்ச்சி , பல்கலைக்கழகம் ஆஃப் இல்லினாய்ஸ் இல் ஊர்பன சாம்பியன் , கொலம்பியா பல்கலைக்கழகம் , மருத்துவ சோதனை பன்முகத்தன்மை , நான்கு பகுதி வெபினார் தொடர் , இடம்பெறும் பார்மா ,

Neuropth Therapeutics snags University of Louisville prof as new CSO

Jan 27, 2021 9:50am
Neurophth is developing its most advanced program, NR082, for an inherited form of vision loss called Leber hereditary optic neuropathy. (LionFive / Pixabay)
Qiutang Li, Ph.D. (Neurophth)
Wuhan Neurophth Biotechnology signed a new chief scientific officer as it moves its gene therapy pipeline toward the clinic. Qiutang Li, Ph.D., joins from the University of Louisville School of Medicine, where she was a professor of ophthalmology and visual sciences for more than 14 years.
Neurophth is working on gene therapies for eye diseases delivered by adeno-associated viruses. As the company’s top scientist, Li will be responsible for global R&D and strategy for its IND portfolio. ....

Lionfive Pixabay Qiutang Li , Qiutang Li , Calvin Luk , Syneos Health , Community Health Leaders , University Of Louisville School Medicine , Clinical Research , Neurophth Biotechnology , Louisville School , Clinical Trial Diversity , Four Part Webinar Series , Featuring Pharma , ஆல்வின் லுக் , சமூக ஆரோக்கியம் தலைவர்கள் , பல்கலைக்கழகம் ஆஃப் லூயிஸ்வில்லி பள்ளி மருந்து , மருத்துவ ஆராய்ச்சி , லூயிஸ்வில்லி பள்ளி , மருத்துவ சோதனை பன்முகத்தன்மை , நான்கு பகுதி வெபினார் தொடர் , இடம்பெறும் பார்மா ,