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Possible alternative to antibiotics produced

<p><strong>Many bacteria produce substances to gain an advantage over competitors in their highly competitive natural environment. Researchers at the University Hospital Bonn (UKB), the University of Bonn and the German Center for Infection Research (DZIF) have discovered a new so-called lantibiotic, namely epilancin A37. It is produced by staphylococci that colonize the skin and acts specifically against their main competitors there, the corynebacteria. This specificity is presumably mediated by a very special mechanism of action, which the researchers were able to decipher in detail. Their results have now been published in the renowned ISME Journal.</strong></p>
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Nordrhein Westfalen , Tanja Schneider , Ulrich Kubitscheck , Fabian Grein , University Hospital Bonn , German Center , Transdisciplinary Research Area , German Research Foundation , University Of Bonn , Life Health , Infection Research , Institute Of Pharmaceutical Microbiology , Pharmaceutical Microbiology , Biophysical Chemistry , Jan Samuel Puls , Thomas Flie , German Research ,

Scientists Decode New Antibiotic

A cooperation between the University of Bonn, the USA, and the Netherlands cracks the mode of action of clovibactin. The rise in bacterial pathogens with resistance is alarming. Common medications are at a growing risk of becoming ineffective against infectious diseases. Consequently, global scient ....

North Carolina , United States , Nordrhein Westfalen , Theresa Harbig , Maikgn Derks , Christopherj Schwalen , Kim Lewis , Yangping Liu , Eefjan Breukink , Francesca Lavore , Tanja Schneider , Marc Baldus , Anthony Nitti , Wouterh Roos , Raj Kumar , Annikam Krueger , Fabian Grein , Kevinc Ludwig , Rodrigov Honorato , Catherine Achorn , Amyl Spoering , Markus Weingarth , Kay Nieselt , Bram Ja Vermeulen , Ulrich Kubitscheck , Moreno Lelli ,

Researchers decode new antibiotic

Cooperation between the University of Bonn, the USA and the Netherlands cracks the mode of action of clovibactin
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North Carolina , United States , Sesto Fiorentino , Nordrhein Westfalen , Rodrigov Honorato , Annikam Krueger , Markus Weingarth , Tanja Schneider , Christopherj Schwalen , Alexandre Bonvin , Anthony Nitti , Francesca Lavore , Ulrich Kubitscheck , Moreno Lelli , Catherine Achorn , Theresa Harbig , Kim Lewis , Eefjan Breukink , Maikgn Derks , Yangping Liu , Kevinc Ludwig , Raj Kumar , Consorzio Interuniversitario Risonanze Magnetiche , Kay Nieselt , Amyl Spoering , Wouterh Roos ,

Blocked cell wall formation stops bacterial c

We still do not understand exactly how antibiotics kill bacteria. However, this understanding is necessary if we want to develop new antibiotics. And that is precisely what is urgently needed, because bacteria are currently showing more and more resistance to existing antibiotics. Therefore, researchers from the University Hospital Bonn (UKB) and the University of Bonn used high-performance microscopes to observe the effect of different antibiotics on the cell division of Staphylococcus aureus. They found that the biosynthesis of peptidoglycan, core component of the bacterial cell wall, is the driving force during the entire process of cell division. In addition, they clarified how exactly different antibiotics block cell division within a few minutes. The results have now been published in the journal Science Advances. ....

Nordrhein Westfalen , Ulrich Kubitscheck , Tanja Schneider , Fabian Grein , Dominik Brajtenbach , Infection Research , Institute Of Pharmaceutical Microbiology , University Of Bonn , Collaborative Research Center , University Hospital Bonn , German Center , Biophysical Chemistry , Jan Samuel Puls , Pharmaceutical Microbiology , Research Center ,