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Frontiers | Crystal structures of glycoprotein D of equine alphaherpesviruses reveal potential binding sites to the entry receptor MHC-I

Cell entry of most alphaherpesviruses is mediated by the binding of glycoprotein D (gD) to different cell surface receptors. Equine herpesvirus type 1 (EHV-1) and EHV-4 gDs interact with equine major histocompatibility complex I (MHC-I) to initiate entry into equine cells. We have characterized the gD-MHC-I interaction by solving the crystal structures of EHV-1 and EHV-4 gDs (gD1, gD4), performing protein-protein docking simulations, surface plasmon resonance (SPR) analysis, and biological assays. The structures of gD1 and gD4 revealed the existence of a common V-set immunoglobulin-like (IgV-like) core comparable to those of other gD homologs. Molecular modeling yielded plausible binding hypotheses and identified key residues (F213 and D261) that are important for virus binding. Altering the key residues resulted in impaired virus growth in cells, which highlights the important role of these residues in the gD-MHC-I interaction. Taken together, our results add to our understanding of t ....

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Expresso | Cinco pessoas morrem ao tentar escalar o monte Elbrus na Rússia

Expresso | Cinco pessoas morrem ao tentar escalar o monte Elbrus na Rússia
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Expresso | Cinco detidos e 19 vítimas de tráfico resgatadas em Portugal em operação da Interpol

Expresso | Cinco detidos e 19 vítimas de tráfico resgatadas em Portugal em operação da Interpol
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Expresso | Cinco museus nacionais têm novos diretores

Expresso | Cinco museus nacionais têm novos diretores
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Services Of Inventory , History The University Of Lisbon , Museum National Of Music , Management Of University Art Lisbon , Museum National , Human Of University , Museum National Of Art , A Museum National , Palace National Of Mafra , Ministry Of Culture , Division Of Culture , Port Of University Catholic Portuguese , Museum Of Guard , Services Supporting To Art , Department Of Heritage Immaterial , College Of Letters University Lisbon , Museum National Of Archeology , Anthropology The College Of Social Science , Museum National The Coaches , Museum Anastacio Gonalves , Museum Of Art Folk , Museum National Of Ethnology , Institute Top Of Economy , Museum National Of Resistance , Museum Tavares Junior In Castle White , Museologist On Museum National Of Resistance ,

Expresso | Cinco anos depois do referendo, os fantasmas do 'Brexit' continuam à solta

Expresso | Cinco anos depois do referendo, os fantasmas do 'Brexit' continuam à solta
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