Data describe induced pluripotent stem cell -derived excitatory neurons as a human model for assessing selectivity of drug binding to soluble amyloid beta oligomers in Alzheimer’s diseaseResults. | March 28, 2023
Landmark Study Identifies The Neurons Especially Vulnerable to Alzheimer s Disease
ELEFTHERIA KODOSAKI, THE CONVERSATION
19 JANUARY 2021
Alzheimer s disease is a devastating condition that is currently unstoppable and incurable. The main cause of the disease is the loss of neurons and other brain cells in the brain – also know as degeneration. This degeneration is what leads to problems with memory and other cognitive functions.
Researchers can tell which neurons die first or exhibit increased vulnerability to Alzheimer s disease based on where they re located in the brain and what they look like.
But they don t know what genes or proteins these neurons express. Knowing these factors is important for recognising and identifying the changes in specific cells that happen when disease is present.